MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl

Product Name: MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
CAS No.: 856307-27-2
Chemical Name: MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
Synonyms: Metamizole EP Impurity C;Metamizole EP Impurity C HCl;4-Methylamino-1,5-dimethyl-2-phenyl;4-Methylaminophenazone Hydrochloride;4-Methylaminoantipyrine hydrochloride;Metamizole EP Impurity C Hydrochloride;N-Methyl-4-aminoantipyrine Hydrochloride;Antipyrine,4-(methylamino)-, hydrochloride;Metamizole EP Impurity C (as Hydrochloride);4-Methylaminoantipyrine hydrochloride in methanol
CBNumber: CB62706986
Molecular Formula: C12H16ClN3O
Formula Weight: 253.73
MOL File: 856307-27-2.mol

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MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl Property

Melting point:: >195°C
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Water (Slightly)
form: Solid
color: Pale Orange to Light Brown
Stability:: Hygroscopic
InChI: 1S/C12H15N3O.ClH/c1-9-11(13-2)12(16)15(14(9)3)10-7-5-4-6-8-10;/h4-8,13H,1-3H3;1H
InChIKey: NNONRTWOIVTAHL-UHFFFAOYSA-N
SMILES: O=C1C(NC)=C(C)N(C)N1C2=CC=CC=C2.[H]Cl

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0114022
Product name: 4-Methylaminoantipyrine(hydrochloride)
Packaging: 25mg
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-0114022
Product name: 4-Methylaminoantipyrine(hydrochloride)
Packaging: 50mg
Price: $155
Updated: 2021/12/16

ChemScene

Product number: CS-0114022
Product name: 4-Methylaminoantipyrine(hydrochloride)
Packaging: 100mg
Price: $245
Updated: 2021/12/16

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MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl Chemical Properties,Usage,Production

Uses

4-Methylaminoantipyrine Hydrochloride is a useful research chemical, a methylamino antipyrine derivatives.

Biological Activity

4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. It has analgesic, antipyretic and relatively weak anti-inflammatory properties.

in vitro

Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.

in vivo

The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of it is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.

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MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl Suppliers

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856307-27-2, MetaMizole IMpurity C (4-MethylaMinoantipyrine) HClRelated Search:

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856307-27-2