Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Product Name: Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
CAS No.: 1157938-97-0
Chemical Name: Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
Synonyms: Voriconazole Impurity 70;1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone;1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one;Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-;Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triaz;Ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-;Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone;Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2;1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone;Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
CBNumber: CB62707857
Molecular Formula: C10H7F2N3O
Formula Weight: 223.18
MOL File: 1157938-97-0.mol

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Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone Property

Boiling point:: 387.6±52.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 2.02±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D462400
Product name: 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
Packaging: 500mg
Price: $130
Updated: 2021/12/16

TRC

Product number: D462400
Product name: 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
Packaging: 1g
Price: $230
Updated: 2021/12/16

Ark Pharm

Product number: AK167575
Product name: 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
Purity: 95+%
Packaging: 1g
Price: $36
Updated: 2021/12/16

Ambeed

Product number: A818342
Product name: 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
Purity: 95+%
Packaging: 1g
Price: $36
Updated: 2021/12/16

Chemenu

Product number: CM195124
Product name: 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
Purity: 95%
Packaging: 1g
Price: $102
Updated: 2021/12/16

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Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone Chemical Properties,Usage,Production

Uses

1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone is a related compound of Isavuconazole (I777830), a triazole antifungal drug.

Synthesis

288-36-8

60468-36-2

1157938-97-0

(A) 1 mol of 2-chloro-2',5'-difluoroacetophenone, 1.2 mol of 1,2,3-triazole, 0.15 mol of cuprous iodide (CuI), 1.5 mol of potassium carbonate, and 0.8 L of N,N-dimethylformamide (DMF) were sequentially added to the reactor, and the reaction was heated to 80 °C and stirred for 10 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was filtered. The filtrate was concentrated under reduced pressure to recover DMF and the residue was recrystallized with ethyl acetate to afford the first product 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone in white solid form in 73% yield.

References

[1] Patent: CN105777740, 2016, A. Location in patent: Paragraph 0019; 0023

Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone Suppliers

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View Lastest Price from Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone 1157938-97-0
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-30

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Isavuconazole Impurity 38 1157938-97-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2025-05-14

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Isavuconazole Impurity 38 1157938-97-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-07-10

1157938-97-0, Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanoneRelated Search:

Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-

Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-

1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one

Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2

Voriconazole Impurity 70

Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triaz

1157938-97-0