ChemicalBook > CAS DataBase List > 1-Methyl-1H-pyrazol-3(2H)-one
1-Methyl-1H-pyrazol-3(2H)-one
- Product Name
- 1-Methyl-1H-pyrazol-3(2H)-one
- CAS No.
- 52867-35-3
- Chemical Name
- 1-Methyl-1H-pyrazol-3(2H)-one
- Synonyms
- 1-Methyl-1,2-dihydro-3H-pyrazol-3-one;EOS-62072;1-Methyl-3-pyrazolone;1-Methylpyrazol-3(2H)-one;1-Methyl-1H-pyrazol-3(2H);1-methyl-3-hydroxypyrazole;3-Hydroxy-1-methylpyrazole;1-METHYL-1H-PYRAZOL-3-OL(WX900134);1-methyl-2,3-dihydro-1H-pyrazol-3-one;3H-Pyrazol-3-one, 1,2-dihydro-1-methyl-
- CBNumber
- CB62710376
- Molecular Formula
- C4H6N2O
- Formula Weight
- 98.1
- MOL File
- 52867-35-3.mol
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1-Methyl-1H-pyrazol-3(2H)-one Property
- Melting point:
- 124-128°C
- Density
- 1.146±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 8.98±0.70(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C4H6N2O/c1-6-3-2-4(7)5-6/h2-3H,1H3,(H,5,7)
- InChIKey
- WIISOYLZJJYTHT-UHFFFAOYSA-N
- SMILES
- N1(C)C=CC(=O)N1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 777846
- Product name
- 3-Hydroxy-1-methyl-1H-pyrazole
- Purity
- 96%
- Packaging
- 1g
- Price
- $125.13
- Updated
- 2025/07/31
TRC
- Product number
- M336238
- Product name
- 1-Methyl-1H-pyrazol-3(2H)-one
- Packaging
- 2.5g
- Price
- $155
- Updated
- 2021/12/16
Ark Pharm
- Product number
- P000723451
- Product name
- 1-Methyl-1H-pyrazol-3(2H)-one
- Purity
- 98%
- Packaging
- 250mg
- Price
- $19
- Updated
- 2021/12/16
Ark Pharm
- Product number
- P000723451
- Product name
- 1-Methyl-1H-pyrazol-3(2H)-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
Ark Pharm
- Product number
- P000723451
- Product name
- 1-Methyl-1H-pyrazol-3(2H)-one
- Purity
- 98%
- Packaging
- 5g
- Price
- $101
- Updated
- 2021/12/16
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1-Methyl-1H-pyrazol-3(2H)-one Chemical Properties,Usage,Production
Synthesis
5788-17-0
52867-35-3
Example 7: General procedure for the synthesis of 1-methyl-1H-pyrazol-3(2H)-one from methyl 3-methoxyacrylate and monomethylhydrazine. In a 250 mL flask, 70 g of methanol and 60.5 g (0.46 mol) of 35% concentration of monomethylhydrazine aqueous solution were first added and the reaction temperature was kept at 25 °C. Subsequently, 47.8 g (0.40 mol) of methyl 3-methoxyacrylate was slowly added dropwise over 25 min. The pH of the reaction mixture was maintained at 12 by parallel dropwise addition of a 17% concentration of aqueous NaOH solution during the dropwise addition and during subsequent stirring for 6 h. A total of 97.5 g of NaOH solution was consumed for this process. The yield of the target product 1-methyl-1H-pyrazol-3(2H)-one was 75% when the reaction reached 100% conversion. The ratio of 3-hydroxy isomer to 5-hydroxy isomer in the product was ≥15:1.
References
[1] Patent: US6392058, 2002, B1
1-Methyl-1H-pyrazol-3(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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