1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE

Product Name: 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE
CAS No.: 289726-02-9
Chemical Name: 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE
Synonyms: MPP2HCl;MPP DiHCl;MMP DIHYDROCHLORIDE;MPP DIHYDROCHLORIDE;Methylpiperidino pyrazole;TXLGPGWHIIHRHH-UHFFFAOYSA-N;METHYL-PIPERIDINO-PYRAZOLE DIHYDROCHLORIDE;Phenol, 4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-1H-pyrazol-3-yl]-;1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE;Methyl-piperidino-pyrazole, 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride
CBNumber: CB6271073
Molecular Formula: C29H31N3O3
Formula Weight: 469.57
MOL File: 289726-02-9.mol

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1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE Property

Boiling point:: 659.2±55.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: DMSO: ≥5 mg/mL, soluble
form: solid
pka: 8.80±0.15(Predicted)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13863
Product name: Methylpiperidino pyrazole
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 13863
Product name: Methylpiperidino pyrazole
Purity: ≥98%
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 13863
Product name: Methylpiperidino pyrazole
Purity: ≥98%
Packaging: 50mg
Price: $632
Updated: 2024/03/01

Tocris

Product number: 1991
Product name: MPPdihydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $186
Updated: 2021/12/16

Tocris

Product number: 1991
Product name: MPPdihydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $782
Updated: 2021/12/16

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1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

MPP is a high affinity silent antagonist at ERα.

Biological Activity

Selective, high affinity silent antagonist at ERa receptors. Displays > 200-fold selectivity for ERa over ERb. K i values are 2.7 and 1800 nM at ERa and ERb receptors respectively.

in vitro

mpp elicited significant apoptosis in the endometrial cancer cell lines, rl-95 cells, and ovine luminal endometrial cell lines relative to the vehicle-treated cells. it was indicated that selective estrogen receptor modulators-induced apoptosis is ascribed to genomic actions instead of toxicity, which was due to the low percentage of apoptosis reduced by the addition of a 10-fold excess of β-estradiol [1].

in vivo

wild-type (wt) cf1 and estrogen receptor-β knockout (erbko) female mice were injected intraperitoneally with two dosages 24 hr apart of 100 mg and 150 mg of mpp, 50 mg and 50 mg mpp, respectively. mpp significantly increased uterine weight and cell proliferation when compared to the vehicle control in wt and erbko mice. however, compared to the control groups, mpp did not effectively increase uterine wet weight. mpp treatment of ovariectomized mice activated apoptosis of the underlying uterine stromal cells without triggering apoptosis of the luminal epithelial cells [1].

IC 50

80 nm: blocks the transcriptional activation of the estrogen receptor (er) α.

References

[1]. davis, a., ellersieck, m., grimm, k., & rosenfeld, c. the effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (mpp), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. molecular reproduction and development. 2006; 73(8): 1034-1044.

1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE Suppliers

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289726-02-9, 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDERelated Search:

1,3-DIPHENYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE 5-(4-METHOXYPHENYL)-1-PHENYL-1H-PYRAZOLE 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE

METHYL-PIPERIDINO-PYRAZOLE DIHYDROCHLORIDE

1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-[4-(2-PIPERIDINYLETHOXY)PHENOL]-1H-PYRAZOLE DIHYDROCHLORIDE

MPP DIHYDROCHLORIDE

MMP DIHYDROCHLORIDE

MPP2HCl

Methyl-piperidino-pyrazole, 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride

Methylpiperidino pyrazole

TXLGPGWHIIHRHH-UHFFFAOYSA-N

MPP DiHCl

Phenol, 4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-1H-pyrazol-3-yl]-

289726-02-9

C29H31N3O32HCl

Intracellular receptor