ledipasvir interMediate

Product Name: ledipasvir interMediate
CAS No.: 1441673-92-2
Chemical Name: ledipasvir interMediate
Synonyms: Ledipasvir INT 1;edipasvir interMediate;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dim...;potassiuM (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester potassiuM salt;(6S)?-?5-?Azaspiro[2.4]?heptane-?5,?6-?dicarboxylicacid5-?(1,?1-?dimethylethyl)esterpotassiumsal;5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt, (6S)-;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt (1:1);5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt (1:1), (6S)-
CBNumber: CB62710886
Molecular Formula: C12H20KNO4
Formula Weight: 281.39
MOL File: 1441673-92-2.mol

More

Less

ledipasvir interMediate Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: A965633
Product name: (6s)-5-Azaspiro[2.4]Heptane-5,6-DicarboxylicAcid5-(1,1-Dimethylethyl)EsterPotassiumSalt(1:1)
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-M2948
Product name: Potassium(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate
Packaging: 1g
Price: $68
Updated: 2021/12/16

AK Scientific

Product number: 2888AH
Product name: (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylicacid5-(1,1-dimethylethyl)esterpotassiumsalt
Packaging: 100mg
Price: $84
Updated: 2021/12/16

Crysdot

Product number: CD11256051
Product name: Potassium(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate
Purity: 95+%
Packaging: 1g
Price: $226
Updated: 2021/12/16

Chemenu

Product number: CM128196
Product name: potassium(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate
Purity: 95%
Packaging: 1g
Price: $271
Updated: 2021/12/16

More

Less

ledipasvir interMediate Chemical Properties,Usage,Production

Synthesis

1129634-44-1

1441673-92-2

E. Potassium salt formation (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid (219 g) was dissolved in 2-methyltetrahydrofuran (880 mL) and the solution was subsequently heated to 35 °C. A THF solution of 1.0 M potassium tert-butanolate (1.05 L) was slowly added while maintaining an internal temperature not exceeding 40 °C. The reaction mixture was stirred for about 30 minutes, followed by slow cooling to 20°C over about 2 hours. After aging at 20 °C for 1 h, a filtration operation was performed. The filter cake was washed with 2-methyltetrahydrofuran (715 mL). The resulting solid was placed in a vacuum oven and dried at 40 °C for 24 h to give potassium (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate (212 g, 86% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ 4.07 (t, J = 7.3 Hz, 1H), 3.44 (d, J = 10.4 Hz, 1H), 3.35 (s, 1H), 3.10 (d, J = 10.4 Hz, 1H), 2.03 (dd, J = 12.3, 6.9 Hz, 1H), 1.89 (dd, J = 12.3, 8.0 Hz, 1H), 1.38 (s, 9H), 0.71-0.27 (m, 4H). 1H NMR (400 MHz, d6-DMSO) δ: 3.89 (dd, J = 8.6, 4.1 Hz, 0.4H, rotary isomer 1), 3.85 (dd, J = 8.6, 4.3 Hz, 0.6H, rotary isomer 2), 3.21-3.07 (m, 2H), 2.00-1.92 (m, 1H), 1.75-1.71 (m, 1H), 1.36 (s, 4H, rotary isomer 1), 1.32 (s, 5H, rotary isomer 2), 0.46-0.37 (m, 4H). 13C NMR (100 MHz, d6-DMSO) δ 174.5, 174.4, 154.1, 153.4, 77.2, 76.9, 62.3, 62.0, 54.1, 53.8, 38.7, 28.4, 28.3, 20.6, 19.9, 18.8, 11.6, 10.5, 10.2.

References

[1] Patent: US2013/324496, 2013, A1. Location in patent: Paragraph 0236-0237
[2] Patent: CN104478791, 2017, B. Location in patent: Paragraph 0069; 0070; 0071; 0072

ledipasvir interMediate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ledipasvir interMediate Suppliers

China 95 India 1 United States 3 Global 99

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 21-33585366 13311639313
Fax: +86-21-34979012
Email: sales@shyrchem.com
Country: China
ProdList: 806
Advantage: 55

ShenZhen InnoSyn Biotech Co.,Ltd

Tel: 0755-28351685 18503098468
Fax: +86-755-28466854
Email: innosyn@163.com
Country: China
ProdList: 602
Advantage: 55

Acesys Pharmatech

Tel: 18860950986
Email: tangmanman@zenjipharma.com
Country: China
ProdList: 1733
Advantage: 55

Shanghai Twisun Bio-pharm Co.,Ltd

Tel: +86-21-33282107
Fax: +86-21-37285115
Country: China
ProdList: 107
Advantage: 60

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 0512-62857507
Fax: +86-512-62857507
Email: sales@sinorarechem.com
Country: China
ProdList: 991
Advantage: 58

Shanghai Balmxy Pharmaceutical Co., Ltd

Tel: 021-24206007 13764915196
Fax: 86-021-23027023
Email: sales@balmxy.com
Country: China
ProdList: 6874
Advantage: 55

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Mixiu Chemical Co., Ltd.

Tel: 18101936766
Fax: 021-58583907
Email: eileen@shmychem.com
Country: China
ProdList: 350
Advantage: 55

Shanghai Peiyang Chemical Co., Ltd.

Tel: +86 (21) 61919736
Fax: +86 (21) 61919739
Country: China
ProdList: 239
Advantage: 55

More

Less

View Lastest Price from ledipasvir interMediate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester potassiuM salt 1441673-92-2
Price: US $0.00-0.00/KG
Min. Order: 5g
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-25

Career Henan Chemical Co

Product: ledipasvir interMediate 1441673-92-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

1441673-92-2, ledipasvir interMediateRelated Search:

(R)-3-Amino-1,2,3,4-tetrahydrocarbazole Ledipasvir ledipasvir interMediate ledipasvir interMediate 2,7-DibroMo-9,9-difluoro-9H-fluorene (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-(6-broMo-1H-benziMidazol-2-yl)-, 1,1-diMethylethyl ester,(1R,3S,4S)- (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone ledipasvir interMediate (3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

potassiuM (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate

(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester

(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester potassiuM salt

(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt (1:1)

edipasvir interMediate

Ledipasvir INT 1

5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt (1:1), (6S)-

5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt, (6S)-

(6S)?-?5-?Azaspiro[2.4]?heptane-?5,?6-?dicarboxylicacid5-?(1,?1-?dimethylethyl)esterpotassiumsal

(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dim...

1441673-92-2

256387-87-7

C12H18NO4K

C12H18KNO4