5-METHOXYBENZOTHIAZOLE

Product Name: 5-METHOXYBENZOTHIAZOLE
CAS No.: 2942-14-5
Chemical Name: 5-METHOXYBENZOTHIAZOLE
Synonyms: 5-METHOXYBENZOTHIAZOLE;Benzothiazole,5-Methoxy-;5-Methoxybenzo[d]thiazole;5-Methoxy-1,3-benzothiazol;5-Methoxy-1,3-benzothiazole;Benzothiazole, 5-methoxy- (7CI,8CI,9CI)
CBNumber: CB6271174
Molecular Formula: C8H7NOS
Formula Weight: 165.21
MOL File: 2942-14-5.mol

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5-METHOXYBENZOTHIAZOLE Property

Melting point:: 38.5-39 °C(Solv: benzene (71-43-2))
Boiling point:: 274.4±13.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 1.44±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 29342000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M331795
Product name: 5-Methoxybenzo[d]thiazole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 2987AB
Product name: 5-Methoxybenzo[d]thiazole
Packaging: 100mg
Price: $93
Updated: 2021/12/16

AK Scientific

Product number: 2987AB
Product name: 5-Methoxybenzo[d]thiazole
Packaging: 250mg
Price: $118
Updated: 2021/12/16

AK Scientific

Product number: 2987AB
Product name: 5-Methoxybenzo[d]thiazole
Packaging: 1g
Price: $253
Updated: 2021/12/16

Apolloscientific

Product number: OR55451
Product name: 5-Methoxy-1,3-benzothiazole
Purity: 95%
Packaging: 250mg
Price: $290
Updated: 2021/12/16

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5-METHOXYBENZOTHIAZOLE Chemical Properties,Usage,Production

Uses

5-Methoxybenzo[d]thiazole is used as a reactant in the preparation of 3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamides as a potent dipeptidyl peptidase IV inhibitors.

Synthesis

54346-87-1

2942-14-5

General procedure for the synthesis of 5-methoxybenzo[d]thiazole from 5-methoxy-2-benzothiazolamine: 5-methoxybenzo[d]thiazol-2-amine (397 mg, 2.2 mmol) was dissolved in tetrahydrofuran (THF, 16 mL). Tert-butyl nitrite (0.375 mL, 3.17 mmol) was slowly added to the solution at 60 °C and the reaction mixture was continuously stirred overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator. The crude product obtained was purified by silica gel column chromatography (SNAP 10 g column, eluent was hexane/ethyl acetate mixed solvent) to finally obtain 5-methoxybenzo[d]thiazole (281 mg, 77.3% yield) as a yellow solid.

References

[1] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0376
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 6, p. 1976 - 1980

5-METHOXYBENZOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHOXYBENZOTHIAZOLE Suppliers

China 40 Europe 1 United States 5 Global 46

J & K SCIENTIFIC LTD.

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2942-14-5, 5-METHOXYBENZOTHIAZOLERelated Search:

5-Methoxy-2-methylbenzothiazole 5,6-DIMETHOXY-2-METHYL-BENZOTHIAZOLE 2-MERCAPTO-5-METHOXYBENZOTHIAZOLE Benzothiazole, 2-chloro-5-methoxy- (6CI,7CI,8CI,9CI) 5-METHOXY-2-METHYL-3-(3-SULFOPROPYL)BENZOTHIAZOLIUM INNER SALT 2-METHYL-5-METHOXY-6-METHYLTHIO BENZOTHIAZOLE 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Benzothiazole, 5-ethoxy-2,6-dimethyl- (9CI) 3-CARBOXYETHYL-2-(2-((3-CARBOXYETHYL-5-METHYL-6-METHOXY-2-BENZOTHIAZOLINYLIDENE) METHYL)-1-BUTENYL)-5-METHYL-6-METHOXY BENZOTHIAZOLIUM IODIDE 3-ETHYL-2-[5-(3-ETHYL-5-METHOXY-6-METHYL MERCAPTO-2-BENZOTHIAZOLINYLIDENE)-1,3-PENTADIENYL)-5-METHOXY-6-METHYLMERCAPTO-BENZOTHIAZOLIUM PARATOLUENESULFONATE 5-METHOXY-3-(3-SULFOPROPYL)-2-[(1-6-METHYL-(3-SULFOPROPYL)-2(1H)-QUINOLYLIDENE)METHYL]BENZOTHIAZOLIUM INNER SALT POTASSIUM SALT TRIHYDRATE 3-CARBOXYETHYL-2-(2-((3-CARBOXYETHYL-5-METHYL-6-METHOXY-2-BENZOTHIAZOLINYLIDENE) METHYL)-1-BUTENYL)-5-METHYL-6-METHOXY BENZOTHIAZOLIUM BROMIDE 3-(2-HYDROXYETHYL)-2-[2-[[3-(2-HYDROXYETHYL)-5-METHOXY-2-BENZOTHIAZOLYLIDENE]METHYL]-1-BUTENYL]-5-METHOXYBENZOTHIAZOLIUM TOSYLATE 3-ETHYL-2-(3-(3-ETHYL-5,6-METHYLENEDIOXY-2-BENZOTHIAZOLINYLIDENE)-1-PROPENYL-5,6-METHYLENEDIOXY) BENZOTHIAZOLIUM ETHYL SULFATE 3-(3-SULFOPROPYL)-2-([5-METHOXY-3-(3-SULFOPROPYL)-2,3-DIHYDRO-BENZOTHIAZOL-2-YLIDNE]METHYL)-NAPHTHO[1,2-D]-THIAZOLIUM INNER SALT TRIETHYLAMMONIUM SALT 3-ETHYL-2-(2-METHOXY-5-(3-ETHYL-5,6-METHYLENEDIOXY BENZOTHIAZOLINYLIDENE)-1,3-PENTADIENYL)-5,6-METHYLENEDIOXY BENZOTHIAZOLIUM BROMIDE 5-METHOXY-3-(3-SULFOPROPYL)-2-(2-[(5-METHOXY-3-(3-SULFOPROPYL)-2,3-DIHYDRO-BENZOTHIAZOL-2-YLIDENE)METHYL]-1-BUTENYL)-BENZOTHIAZOLIUM INNER SALT PYRIDINIUM SALT AURORA KA-327

5-METHOXYBENZOTHIAZOLE

Benzothiazole,5-Methoxy-

5-Methoxybenzo[d]thiazole

Benzothiazole, 5-methoxy- (7CI,8CI,9CI)

5-Methoxy-1,3-benzothiazol

5-Methoxy-1,3-benzothiazole

2942-14-5

BENZOTHIAZOLE