5-BroMo-1-ethylpyridin-2(1h)-one
- Product Name
- 5-BroMo-1-ethylpyridin-2(1h)-one
- CAS No.
- 63785-87-5
- Chemical Name
- 5-BroMo-1-ethylpyridin-2(1h)-one
- Synonyms
- 5-Bromo-1-ethylpyridin-2-one;5-Bromo-1-ethyl-1H-pyridin-2-one;5-BroMo-1-ethylpyridin-2(1h)-one;2(1H)-Pyridinone, 5-bromo-1-ethyl-
- CBNumber
- CB62714334
- Molecular Formula
- C7H8BrNO
- Formula Weight
- 202.05
- MOL File
- 63785-87-5.mol
5-BroMo-1-ethylpyridin-2(1h)-one Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B613815
- Product name
- 5-Bromo-1-ethylpyridin-2(1H)-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3102AJ
- Product name
- 5-Bromo-1-ethyl-1H-pyridin-2-one
- Packaging
- 5g
- Price
- $762
- Updated
- 2021/12/16
- Product number
- 153157
- Product name
- 5-Bromo-1-ethylpyridin-2(1H)-one
- Purity
- 95%
- Packaging
- 5g
- Price
- $1444
- Updated
- 2021/12/16
- Product number
- 153157
- Product name
- 5-Bromo-1-ethylpyridin-2(1H)-one
- Purity
- 95%
- Packaging
- 10g
- Price
- $1814
- Updated
- 2021/12/16
- Product number
- CM121049
- Product name
- 5-Bromo-1-ethylpyridin-2(1H)-one
- Purity
- 95%
- Packaging
- 10g
- Price
- $898
- Updated
- 2021/12/16
5-BroMo-1-ethylpyridin-2(1h)-one Chemical Properties,Usage,Production
Synthesis
13466-38-1
75-03-6
63785-87-5
At room temperature, 5-bromo-1,2-dihydropyridin-2-one (1.04 g, 6 mmol) was dissolved in DMF (12 mL), sodium hydride (60% dispersion in mineral oil, 960 mg, 24 mmol) was added and the reaction mixture was stirred for 30 minutes. Subsequently, ethyl iodide (0.58 mL, 7.2 mmol) was slowly added to the reaction system and stirring was continued overnight at room temperature. This operation was repeated twice to ensure complete reaction. Upon completion of the reaction, the mixture was diluted with water and dichloromethane (DCM). The organic layer was separated, washed sequentially with saturated sodium bicarbonate solution and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: DCM/MeOH 98/2) to afford the target compound 5-bromo-1-ethylpyridin-2(1H)-one (532 mg, 2.63 mmol, 44% yield).
References
[1] Patent: EP2913330, 2015, A1. Location in patent: Paragraph 0526
[2] Patent: WO2011/154677, 2011, A1. Location in patent: Page/Page column 111-112
[3] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 17, p. 2993 - 2997
5-BroMo-1-ethylpyridin-2(1h)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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