GSK2194069

Product Name: GSK2194069
CAS No.: 1332331-08-4
Chemical Name: GSK2194069
Synonyms: GSK2194069;GSK2194069 >=97% (HPLC);GSK2194069 (GSK 2194069;4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one;(S)-4-(4-(benzofuran-5-yl)phenyl)-5-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one;3H-1,2,4-Triazol-3-one, 4-[4-(5-benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-
CBNumber: CB62715634
Molecular Formula: C25H24N4O3
Formula Weight: 428.48
MOL File: 1332331-08-4.mol

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GSK2194069 Property

Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF:30.0(Max Conc. mg/mL);70.01(Max Conc. mM)
DMSO:54.28(Max Conc. mg/mL);126.68(Max Conc. mM)
Ethanol:4.91(Max Conc. mg/mL);11.46(Max Conc. mM)
form: powder
pka: 6.15±0.20(Predicted)
color: white to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1259
Product name: GSK2194069
Purity: ≥97% (HPLC)
Packaging: 5MG
Price: $196
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1259
Product name: GSK2194069
Purity: ≥97% (HPLC)
Packaging: 25MG
Price: $787
Updated: 2023/06/20

Cayman Chemical

Product number: 20022
Product name: GSK2194069
Purity: ≥98%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20022
Product name: GSK2194069
Purity: ≥98%
Packaging: 1mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 20022
Product name: GSK2194069
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

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GSK2194069 Chemical Properties,Usage,Production

Uses

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor.

Biochem/physiol Actions

GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 ± 0.5 nM.

storage

Store at +4°C

GSK2194069 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2194069 Suppliers

China 43 United Kingdom 1 United States 10 Global 54

Haoyuan Chemexpress Co., Ltd.

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Sigma-Aldrich

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1332331-08-4, GSK2194069Related Search:

GSK2194069

4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

GSK2194069 (GSK 2194069

3H-1,2,4-Triazol-3-one, 4-[4-(5-benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-

GSK2194069 >=97% (HPLC)

(S)-4-(4-(benzofuran-5-yl)phenyl)-5-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

1332331-08-4