1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone

Product Name: 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
CAS No.: 1190865-44-1
Chemical Name: 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
Synonyms: 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one;Sealed in dry,Room Temperature;3',5'-DICHLORO-2,2,2,4'-TETRAFLUOROACETOPHENONE;2,2,2-Trifluoro-3',5'-dichloro-4'-fluoroacetophenone;1-(3,5-Dichloro-4-fluoropheny)-2,2,2-trifluoroethanone;1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone;Ethanone, 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-;1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one (Sarolaner intermediate）;1-(3,5-dichloroChemicalbook-4-fluorophenyl)-2,2,2-trifluoroethan-1-one(Sarolanerintermediate）;1(3,5Dichloro4fluorophenyl)2,2,2trifluoroethanone,1 (3,5 Dichloro 4 fluorophenyl) 2,2,2 trifluoroethanone
CBNumber: CB62716626
Molecular Formula: C8H2Cl2F4O
Formula Weight: 261.0004928
MOL File: 1190865-44-1.mol

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1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone Property

Boiling point:: 282.5±40.0 °C(Predicted)
Density: 1.577±0.06 g/cm3(Predicted)
vapor pressure: 20-2750Pa at 20-37.8℃
storage temp.: Sealed in dry,Room Temperature
form: Liquid
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C8H2Cl2F4O/c9-4-1-3(2-5(10)6(4)11)7(15)8(12,13)14/h1-2H
InChIKey: NSWPERXXSPCRCT-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(Cl)=C(F)C(Cl)=C1)C(F)(F)F
LogP: 2.57
Surface tension: 61.3mN/m at 1g/L and 20℃

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Safety

HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC49287
Product name: 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone
Packaging: 1g
Price: $36
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2617-7-58
Product name: 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone
Packaging: 1g
Price: $42
Updated: 2021/12/16

Apolloscientific

Product number: PC49287
Product name: 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone
Packaging: 5g
Price: $108
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2617-7-58
Product name: 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone
Packaging: 5G
Price: $128
Updated: 2021/12/16

Apolloscientific

Product number: PC49287
Product name: 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone
Packaging: 25g
Price: $337
Updated: 2021/12/16

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1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone Chemical Properties,Usage,Production

Uses

1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone can be used as a pesticide intermediate, mainly in the synthesis of sarolaner.

Synthesis

340-07-8

17318-08-0

1190865-44-1

The general procedure for the synthesis of 3,5-dichloro-4-fluorotrifluoroacetylbenzene from 1-trifluoroacetylpiperidine and 3,5-dichloro-4-fluorobromobenzene is as follows: Intermediate 3: Synthesis of 1-(4-chloro-3,5-difluorophenyl)-2,2,2-trifluoroacetophenone 1. 5-bromo-2-fluoro-1,3-dichlorobenzene (7.0 g, 28.7 mmol) was dissolved in THF (50 mL) under argon protection and stirred at room temperature. 2. isopropylmagnesium chloride lithium chloride complex (24.3 mL, 1.3 M solution in THF, 1.1 equiv) was added slowly over 1 min and stirring was continued at room temperature for 30 min. 3. The reaction system was cooled to 0 °C and piperidine trifluoroacetamide (5.6 mL, 1.32 equiv.) was added over about 1 min. 4. The reaction mixture was stirred at room temperature for 2 hours. 5. Upon completion of the reaction, the reaction was quenched with saturated aqueous NH4Cl solution (50 mL). 6. The reaction mixture was extracted with methyl tert-butyl ether (MTBE, 2 x 50 mL). 7. The organic phases were combined and concentrated under reduced pressure to remove the solvent. 8. The crude product was purified by chromatography on a 12 g Redi-Sep column with the eluent being a heptane solution of 0 to 50% ethyl acetate to give 3.5 g of 1-(4-chloro-3,5-difluorophenyl)-2,2,2-trifluoroethanone. Product Characterization: 1H-NMR (400 MHz, CDCl3) δ ppm 8.06 (dd, 2H, J1 = 6.2 Hz, J2 = 0.9 Hz).

References

[1] Patent: WO2016/115315, 2016, A1. Location in patent: Page/Page column 30; 31

1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone Suppliers

China 145 India 5 United Kingdom 1 United States 8 Global 159

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View Lastest Price from 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-Ethanone 1190865-44-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-09-22

Chongqing Soarwin Technology Co., Ltd

Product: 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone 1190865-44-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2025-04-10

Shaanxi Dideu New Materials Co. Ltd

Product: 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone 1190865-44-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-01

1190865-44-1, 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanoneRelated Search:

1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

2,2,2-Trifluoro-3',5'-dichloro-4'-fluoroacetophenone

Ethanone, 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one (Sarolaner intermediate）

1(3,5Dichloro4fluorophenyl)2,2,2trifluoroethanone,1 (3,5 Dichloro 4 fluorophenyl) 2,2,2 trifluoroethanone

Sealed in dry,Room Temperature

3',5'-DICHLORO-2,2,2,4'-TETRAFLUOROACETOPHENONE

1-(3,5-dichloroChemicalbook-4-fluorophenyl)-2,2,2-trifluoroethan-1-one(Sarolanerintermediate）

1-(3,5-Dichloro-4-fluoropheny)-2,2,2-trifluoroethanone

1190865-44-1