8-Bromo-1-octanol
- Product Name
- 8-Bromo-1-octanol
- CAS No.
- 50816-19-8
- Chemical Name
- 8-Bromo-1-octanol
- Synonyms
- 8-bromooctan-1-ol;S,1000;8-BROMOOCTANOL;8-bromo-1-octano;8-Bromo-1-actanol;8-BROMO-1-OCTANOL;8-BroMo-1-oCLanol;8-Bromooctane-1-ol;1-bromo-octan-8-ol;1-Octanol, 8-bromo-
- CBNumber
- CB6271684
- Molecular Formula
- C8H17BrO
- Formula Weight
- 209.12
- MOL File
- 50816-19-8.mol
8-Bromo-1-octanol Property
- Boiling point:
- 79-80 °C/0.07 mmHg (lit.)
- Density
- 1.22 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.480(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- Oil
- pka
- 15.19±0.10(Predicted)
- color
- Colourless
- Specific Gravity
- 1.22
- BRN
- 1900837
- InChI
- InChI=1S/C8H17BrO/c9-7-5-3-1-2-4-6-8-10/h10H,1-8H2
- InChIKey
- GMXIEASXPUEOTG-UHFFFAOYSA-N
- SMILES
- C(O)CCCCCCCBr
- CAS DataBase Reference
- 50816-19-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 8-Bromo-1-octanol(50816-19-8)
- EPA Substance Registry System
- 1-Octanol, 8-bromo- (50816-19-8)
Safety
- Risk Statements
- 36-38
- Safety Statements
- 23-24/25-37-26
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29055900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 294144
- Product name
- 8-Bromo-1-octanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $45.35
- Updated
- 2025/07/31
- Product number
- 294144
- Product name
- 8-Bromo-1-octanol
- Purity
- 95%
- Packaging
- 5g
- Price
- $189
- Updated
- 2025/07/31
- Product number
- B1729
- Product name
- 8-Bromo-1-octanol
- Purity
- >90.0%(GC)
- Packaging
- 5g
- Price
- $126
- Updated
- 2025/07/31
- Product number
- B1729
- Product name
- 8-Bromo-1-octanol
- Purity
- >90.0%(GC)
- Packaging
- 25g
- Price
- $402
- Updated
- 2025/07/31
- Product number
- B997403
- Product name
- 8-Bromooctan-1-ol
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
8-Bromo-1-octanol Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to yellow liquid
Uses
It is used to produce 8-phenylselanyl-octan-1-ol by reaction with diphenyl-diselane. The reaction occurs with reagent sodium borohydride and solvent ethanol at ambient temperature. The yield is about 96%. 8-Bromo-1-octanol was used in the synthesis of (E)-10-hydroxy-2-decenoic acid (royal jelly acid)1. It was also used in the synthesis of (Z)-14-methyl-9-pentadecenoic acid.
reaction suitability
reagent type: cross-linking reagent
Synthesis
629-41-4
50816-19-8
The general procedure for the synthesis of 8-bromo-1-octanol from 1,8-octanediol was as follows: 16 g (110 mmol) of 1,8-octanediol was dissolved in 250 ml of toluene. To the solution was added 15.5 ml of hydrobromic acid (137 mmol, 1.25 eq., 48% aqueous solution), after which the reaction mixture was connected to a Dean-Stark manifold and refluxed to remove the water produced by the reaction. After 8 hours of reaction, the mixture was cooled to room temperature and washed sequentially twice with distilled water and once with brine. After drying over anhydrous sodium sulfate, the mixture was filtered and the solvent evaporated to give 8-bromo-1-octanol in quantitative yield. Nuclear magnetic resonance hydrogen spectroscopy (NMR) showed trace residues of toluene which did not affect the subsequent reaction. Densitometry (D2O calibration): 1.23 g/ml (literature value: 1.22 g/ml).13C NMR (CDCl3, ppm) data were as follows: 62.95 (CH2OH), 34.04 (BrCH2CH2), 32.78/32.71 (BrCH2 and CH2CH2OH), 29.23/28.73/ 28.09/25.65 (CH2).
References
[1] Patent: WO2018/108948, 2018, A1. Location in patent: Page/Page column 55
[2] Tetrahedron, 2008, vol. 64, # 30-31, p. 7369 - 7377
[3] Journal of the American Chemical Society, 1992, vol. 114, # 13, p. 5281 - 5294
[4] Phytochemistry, 1996, vol. 42, # 6, p. 1617 - 1620
[5] Tetrahedron Letters, 2002, vol. 43, # 15, p. 2745 - 2747
8-Bromo-1-octanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-Bromo-1-octanol manufacturers
- Product
- 8-Bromo-1-octanol 50816-19-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 96%+
- Supply Ability
- as request
- Release date
- 2018-12-22