ChemicalBook > CAS DataBase List > 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

Product Name
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
CAS No.
192718-06-2
Chemical Name
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
Synonyms
C527;C527 >=98% (HPLC);2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit
CBNumber
CB62719612
Molecular Formula
C17H8FNO3
Formula Weight
293.25
MOL File
192718-06-2.mol
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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Property

Boiling point:
488.6±47.0 °C(Predicted)
Density 
1.433±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: soluble0.3mg/mL, clear (warmed)
pka
-4.21±0.20(Predicted)
form 
powder
color 
faint yellow to dark yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
46
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1008
Product name
C527
Purity
≥98% (HPLC)
Packaging
5mg
Price
$107
Updated
2022/05/15
Cayman Chemical
Product number
21771
Product name
C527
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
21771
Product name
C527
Purity
≥98%
Packaging
10mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
21771
Product name
C527
Purity
≥98%
Packaging
25mg
Price
$317
Updated
2024/03/01
Cayman Chemical
Product number
21771
Product name
C527
Purity
≥98%
Packaging
50mg
Price
$435
Updated
2024/03/01
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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Chemical Properties,Usage,Production

Biological Activity

C527 is a pan-DUB enzyme inhibitor with high activity against USP1/UAF1 complex with IC50 value of 0.88 μM.

in vitro

Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.

target

0.88 μM (USP1)

2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Suppliers

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192718-06-2, 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dioneRelated Search:


  • 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
  • 2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione
  • C527
  • Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-
  • C527 >=98% (HPLC)
  • Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit
  • 2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione
  • 192718-06-2