CTX0294885

Product Name: CTX0294885
CAS No.: 1439934-41-4
Chemical Name: CTX0294885
Synonyms: CS-1885;CS-1944;CTX0294885;CTx0294885, >99%;CTX-0294885, >=98%;CTX-0294885 ，S0206;CTX-0294885, 10 mM in DMSO;CTX-0294885; CTX 0294885; CTX0294885; CTX 0294885.;2-(5-chloro-2-(4-(piperazin-1-yl)phenylaMino)pyriMidin-4-ylaMino)-N-MethylbenzaMide;2-[[5-Chloro-2-[[4-(1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
CBNumber: CB62729266
Molecular Formula: C22H24ClN7O
Formula Weight: 437.93
MOL File: 1439934-41-4.mol

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CTX0294885 Property

Density: 1.332±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥21.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: solid
pka: 14.57±0.46(Predicted)
color: Light yellow to green yellow
InChIKey: FCLOIQHNUARDSR-UHFFFAOYSA-N
SMILES: C(NC)(=O)C1=CC=CC=C1NC1C(Cl)=CN=C(NC2=CC=C(N3CCNCC3)C=C2)N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22197
Product name: CTX-0294885
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 22197
Product name: CTX-0294885
Purity: ≥98%
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 22197
Product name: CTX-0294885
Purity: ≥98%
Packaging: 10mg
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 22197
Product name: CTX-0294885
Purity: ≥98%
Packaging: 25mg
Price: $553
Updated: 2024/03/01

ApexBio Technology

Product number: B5843
Product name: CTX0294885
Packaging: 10mM(in 1mL DMSO)
Price: $95
Updated: 2021/12/16

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CTX0294885 Chemical Properties,Usage,Production

Uses

CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer[1].

Biological Activity

ctx-0294885 is a novel bisanilino pyrimidine. it has inhibitory activity towards a wild range of kinases in vitro. ctx-0294885 is capable of capturing more than half of the expressed kinome in mda-mb-231 cells. large-scale ctx-0294885-based affinity purification with lc−ms/ms identifies 235 protein kinases. ctx-0294885 binds additional kinases that were not identified from previous studies using other kinase capture reagents. it is further developed into a sepharose-supported kinase capture reagent. ctx-0294885 is a new tool for analysis of kinome signaling networks. [1]

Synthesis

761440-08-8

1215504-60-1

1439934-41-4

The reaction was carried out with 2-((2,5-dichloropyrimidin-4-yl)amino)-N-methylbenzamide (149 mg, 0.503 mmol) and 4-(piperazin-1-yl)aniline hydrochloride (134 mg, 0.627 mmol) as raw materials and stirred for 16 hr at 95 °C in the presence of 2,2,2-trifluoroethanol (5 mL) and concentrated aqueous hydrochloric acid solution (2 drops). Upon completion of the reaction, the mixture was cooled to room temperature, diluted with 5% aqueous sodium hydroxide solution (100 mL) and subsequently extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Purification by reversed-phase column chromatography (12 g C18 column, 0-40% acetonitrile/methanol gradient elution) afforded the crude product was washed with dichloromethane (2 × 2 mL) and dried to afford the target compound 2-((5-chloro-2-((4-(piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide (33.4 mg, 15% yield) as an off-white solid.1H NMR (400 MHz, d6-DMSO) δ 9.19 (s, 1H), 8.78-8.71 (m, 2H), 8.15 (s, 1H), 7.74 (dd, J = 7.8, 1.3 Hz, 1H), 7.49-7.42 (m, 3H), 7.12 (t, J = 7.2 Hz, 1H), 6.86 ( d, J = 9.0 Hz, 2H), 3.00-2.95 (m, 4H), 2.86-2.79 (m, 7H).LCMS: retention time 4.28 min; m/z 438.1 [M + H]+.

References

1. zhang l, holmes ip, hochgräfe f et al. characterization of the novel broad-spectrumkinase inhibitor ctx-0294885 as an affinity reagent for mass spectrometry-basedkinome profiling. j proteome res. 2013 jul 5;12(7):3104-16.

CTX0294885 Preparation Products And Raw materials

Raw materials

Preparation Products

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CTX0294885 Suppliers

China 96 India 1 United States 13 Global 110

Jingmo (Xiamen) Biotechnology Co., Ltd

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View Lastest Price from CTX0294885 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: CTX0294885 1439934-41-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: CTX0294885 1439934-41-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

1439934-41-4, CTX0294885Related Search:

CTX-0294885; CTX 0294885; CTX0294885; CTX 0294885.

CS-1944

CS-1885

CTx0294885, >99%

CTX0294885

2-(5-chloro-2-(4-(piperazin-1-yl)phenylaMino)pyriMidin-4-ylaMino)-N-MethylbenzaMide

2-(5-chloro-2-(4-(piperazin-1-yl)phenylamino)pyrimidin-4-ylamino)-N-methylbenzamide CTX0294885

2-[[5-Chloro-2-[[4-(1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide

CTX-0294885, >=98%

Benzamide, 2-[[5-chloro-2-[[4-(1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-

CTX-0294885, 10 mM in DMSO

CTX-0294885 ，S0206

1439934-41-4

C22H24ClN7O

Inhibitors