5-Chloro-1H-indazole-3-carboxaMide
- Product Name
- 5-Chloro-1H-indazole-3-carboxaMide
- CAS No.
- 28751-70-4
- Chemical Name
- 5-Chloro-1H-indazole-3-carboxaMide
- Synonyms
- 5-Chloro-1H-indazole-3-carboxaMide;1H-Indazole-3-carboxamide, 5-chloro-;5-Chloro-1H-indazole-3-carboxylic acid amide
- CBNumber
- CB62734022
- Molecular Formula
- C8H6ClN3O
- Formula Weight
- 195.61
- MOL File
- 28751-70-4.mol
5-Chloro-1H-indazole-3-carboxaMide Property
- Boiling point:
- 509.6±30.0 °C(Predicted)
- Density
- 1.555±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.24±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- UT01788
- Product name
- 5-Chloro-1H-indazole-3-carboxamide
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $157.04
- Updated
- 2021/12/16
- Product number
- CM124873
- Product name
- 5-chloro-1H-indazole-3-carboxamide
- Purity
- 98%
- Packaging
- 1g
- Price
- $234
- Updated
- 2021/12/16
- Product number
- CD11153371
- Product name
- 5-Chloro-1H-indazole-3-carboxamide
- Purity
- 98%
- Packaging
- 1g
- Price
- $248
- Updated
- 2021/12/16
- Product number
- 28751704
- Product name
- 5-Chloro-1H-indazole-3-carboxamide
- Packaging
- 1g
- Price
- $267.5
- Updated
- 2021/12/16
- Product number
- 61-10762
- Product name
- 5-Chloro-1H-indazole-3-carboxamide
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $585
- Updated
- 2021/12/16
5-Chloro-1H-indazole-3-carboxaMide Chemical Properties,Usage,Production
Synthesis
1077-95-8
28751-70-4
General procedure for the synthesis of 5-chloro-1H-indazole-3-carboxamide from 5-chloro-1H-indazole-3-carboxylic acid: 5-chloro-1H-indazole-3-carboxylic acid (0.8 g, 4.0 mmol) was dissolved in anhydrous THF (20 mL), followed by the sequential addition of isobutyl chloroformate (0.64 mL, 4.9 mmol) and N-methylmorpholine (0.7 mL, 6.1 mmol). The reaction mixture was stirred at 0 °C for 2 h under argon protection. Then, 10 mL of ammonia solution was slowly added to the reaction system and stirring was continued at 25 °C for 1 hour. Upon completion of the reaction, the THF solvent was removed by distillation under reduced pressure. The resulting solid was filtered through a Brinell's funnel and washed with ether and finally dried under vacuum to give a light-colored solid 5-chloro-1H-indazole-3-carboxamide (0.5 g, 63% yield). The product characterization data were as follows: IR (thin film method, cm^-1 ): 2925, 2854, 1463; ^1H NMR (200 MHz, DMSO-d6): δ 8.14 (d, J = X Hz, 1H), 7.80 (br s, 1H), 7.66 (d, J = 8.9 Hz, 1H), 7.45-7.39 (m, 2H); MS ( ESI): m/z 218 ([M + Na]+).
References
[1] Patent: WO2015/15519, 2015, A1. Location in patent: Page/Page column 17; 18
5-Chloro-1H-indazole-3-carboxaMide Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-1H-indazole-3-carboxaMide Suppliers
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- Country
- India
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