Methyl 4-(benzyloxy)-3-hydroxybenzoate
- Product Name
- Methyl 4-(benzyloxy)-3-hydroxybenzoate
- CAS No.
- 87687-75-0
- Chemical Name
- Methyl 4-(benzyloxy)-3-hydroxybenzoate
- Synonyms
- Methyl 4-(benzyloxy)-3-hydroxybenzoate;Methyl 3-hydroxy-4-(phenylmethoxy)benzoate;Benzoic acid, 3-hydroxy-4-(phenylmethoxy)-, methyl ester
- CBNumber
- CB62734431
- Molecular Formula
- C15H14O4
- Formula Weight
- 258.27
- MOL File
- 87687-75-0.mol
Methyl 4-(benzyloxy)-3-hydroxybenzoate Property
- Melting point:
- 129 °C
- Boiling point:
- 436.7±30.0 °C(Predicted)
- Density
- 1.227±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.70±0.35(Predicted)
N-Bromosuccinimide Price
- Product number
- 3934AC
- Product name
- Methyl4-(benzyloxy)-3-hydroxybenzoate
- Packaging
- 1g
- Price
- $297
- Updated
- 2021/12/16
- Product number
- CHM0393154
- Product name
- METHYL-4-(BENZYLOXY)-3-HYDROXYBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.96
- Updated
- 2021/12/16
- Product number
- 87687750
- Product name
- Methyl4-(benzyloxy)-3-hydroxybenzoate
- Packaging
- 1g
- Price
- $568.98
- Updated
- 2021/12/16
- Product number
- CM153964
- Product name
- methyl4-(benzyloxy)-3-hydroxybenzoate
- Purity
- 95%
- Packaging
- 1g
- Price
- $488
- Updated
- 2021/12/16
- Product number
- A168382
- Product name
- Methyl4-(benzyloxy)-3-hydroxybenzoate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $8
- Updated
- 2021/12/16
Methyl 4-(benzyloxy)-3-hydroxybenzoate Chemical Properties,Usage,Production
Synthesis
2150-43-8
100-39-0
87687-75-0
Benzyl bromide (0.78 mL, 6.5 mmol, 1.0 eq.) was added slowly and dropwise to a stirred mixed solution of methyl 3,4-dihydroxybenzoate (1.1 g, 6.5 mmol, 1.0 eq.) and potassium carbonate (1.1 g, 7.8 mmol, 1.2 eq.) in N,N-dimethylformamide (11 mL). The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The crude product was dissolved in water and extracted with ethyl acetate, followed by adjusting the pH of the aqueous phase with 2 M hydrochloric acid to 2. The organic phase was separated and the aqueous phase was re-extracted with ethyl acetate (3×). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using a gradient elution with 5-80% ethyl acetate/isohexane to afford methyl 4-(benzyloxy)-3-hydroxybenzoate as a white solid (0.82 g, 49% yield). NMR hydrogen spectrum (400 MHz, CDCl3) δ 7.62-7.62 (2H, m), 7.43-7.40 (5H, m), 6.94 (1H, d, J = 8.0 Hz), 5.69 (1H, s), 5.17 (2H, s), 3.88 (3H, s).
References
[1] Organic Preparations and Procedures International, 2004, vol. 36, # 5, p. 445 - 452
[2] Organic and Biomolecular Chemistry, 2005, vol. 3, # 11, p. 2114 - 2121
[3] Patent: WO2016/98005, 2016, A1. Location in patent: Page/Page column 63
[4] Patent: CN103130791, 2016, B. Location in patent: Paragraph 0477-0479
[5] European Journal of Medicinal Chemistry, 2018, vol. 151, p. 389 - 400
Methyl 4-(benzyloxy)-3-hydroxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4-(benzyloxy)-3-hydroxybenzoate Suppliers
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 42446
- Advantage
- 60
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- 021-6445-8359 19352137618
- Fax
- QQ：1316418041
- 258399092@qq.com
- Country
- China
- ProdList
- 67
- Advantage
- 56
- Tel
- 022-59987777 13552403979
- jia_guoqiang@wuxiapptec.com
- Country
- China
- ProdList
- 22345
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 8460
- Advantage
- 58
- Tel
- +86-15221114306; +8615221114306
- Fax
- 86-417-4890038
- 2594582574@qq.com
- Country
- China
- ProdList
- 561
- Advantage
- 58
- Tel
- 15151934985
- sales@yingsapharm.com
- Country
- China
- ProdList
- 5185
- Advantage
- 58
- Tel
- 15210893940; 15116916250
- Fax
- QQ: 237008221
- chemistryliu@163.com
- Country
- China
- ProdList
- 7327
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58