Methyl 4-(benzyloxy)-3-hydroxybenzoate

Product Name: Methyl 4-(benzyloxy)-3-hydroxybenzoate
CAS No.: 87687-75-0
Chemical Name: Methyl 4-(benzyloxy)-3-hydroxybenzoate
Synonyms: Methyl 4-(benzyloxy)-3-hydroxybenzoate;Methyl 3-hydroxy-4-(phenylmethoxy)benzoate;Benzoic acid, 3-hydroxy-4-(phenylmethoxy)-, methyl ester
CBNumber: CB62734431
Molecular Formula: C15H14O4
Formula Weight: 258.27
MOL File: 87687-75-0.mol

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Methyl 4-(benzyloxy)-3-hydroxybenzoate Property

Melting point:: 129 °C
Boiling point:: 436.7±30.0 °C(Predicted)
Density: 1.227±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 8.70±0.35(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3934AC
Product name: Methyl4-(benzyloxy)-3-hydroxybenzoate
Packaging: 1g
Price: $297
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0393154
Product name: METHYL-4-(BENZYLOXY)-3-HYDROXYBENZOATE
Purity: 95.00%
Packaging: 5MG
Price: $496.96
Updated: 2021/12/16

Ambeed

Product number: A168382
Product name: Methyl4-(benzyloxy)-3-hydroxybenzoate
Purity: 95%
Packaging: 100mg
Price: $8
Updated: 2021/12/16

Ambeed

Product number: A168382
Product name: Methyl4-(benzyloxy)-3-hydroxybenzoate
Purity: 95%
Packaging: 250mg
Price: $12
Updated: 2021/12/16

Ambeed

Product number: A168382
Product name: Methyl4-(benzyloxy)-3-hydroxybenzoate
Purity: 95%
Packaging: 1g
Price: $31
Updated: 2021/12/16

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Methyl 4-(benzyloxy)-3-hydroxybenzoate Chemical Properties,Usage,Production

Synthesis

2150-43-8

100-39-0

87687-75-0

Benzyl bromide (0.78 mL, 6.5 mmol, 1.0 eq.) was added slowly and dropwise to a stirred mixed solution of methyl 3,4-dihydroxybenzoate (1.1 g, 6.5 mmol, 1.0 eq.) and potassium carbonate (1.1 g, 7.8 mmol, 1.2 eq.) in N,N-dimethylformamide (11 mL). The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The crude product was dissolved in water and extracted with ethyl acetate, followed by adjusting the pH of the aqueous phase with 2 M hydrochloric acid to 2. The organic phase was separated and the aqueous phase was re-extracted with ethyl acetate (3×). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using a gradient elution with 5-80% ethyl acetate/isohexane to afford methyl 4-(benzyloxy)-3-hydroxybenzoate as a white solid (0.82 g, 49% yield). NMR hydrogen spectrum (400 MHz, CDCl3) δ 7.62-7.62 (2H, m), 7.43-7.40 (5H, m), 6.94 (1H, d, J = 8.0 Hz), 5.69 (1H, s), 5.17 (2H, s), 3.88 (3H, s).

References

[1] Organic Preparations and Procedures International, 2004, vol. 36, # 5, p. 445 - 452
[2] Organic and Biomolecular Chemistry, 2005, vol. 3, # 11, p. 2114 - 2121
[3] Patent: WO2016/98005, 2016, A1. Location in patent: Page/Page column 63
[4] Patent: CN103130791, 2016, B. Location in patent: Paragraph 0477-0479
[5] European Journal of Medicinal Chemistry, 2018, vol. 151, p. 389 - 400

Methyl 4-(benzyloxy)-3-hydroxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-(benzyloxy)-3-hydroxybenzoate Suppliers

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87687-75-0, Methyl 4-(benzyloxy)-3-hydroxybenzoateRelated Search:

Methyl 4-(benzyloxy)-3-hydroxybenzoate

Benzoic acid, 3-hydroxy-4-(phenylmethoxy)-, methyl ester

Methyl 3-hydroxy-4-(phenylmethoxy)benzoate

87687-75-0