ChemicalBook > CAS DataBase List > EX-527 (R-enantioMer)
EX-527 (R-enantioMer)
- Product Name
- EX-527 (R-enantioMer)
- CAS No.
- 848193-69-1
- Chemical Name
- EX-527 (R-enantioMer)
- Synonyms
- EX-527(R‰;(R)-Selisistat;EX-527 (R-enantioMer);Selisistat R-enantiomer, 10 mM in DMSO;(R)-SELISISTAT; EX-527(R); EX 527(R); EX527(R);;(R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide;1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1R)-;Sirtuin,Selisistat R enantiomer,inhibit,Selisistat Renantiomer,Inhibitor,(R)-Selisistat
- CBNumber
- CB62735519
- Molecular Formula
- C13H13ClN2O
- Formula Weight
- 248.71
- MOL File
- 848193-69-1.mol
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EX-527 (R-enantioMer) Property
- Boiling point:
- 531.7±38.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 16.12±0.40(Predicted)
- color
- Light yellow to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Usbiological
- Product number
- 474097
- Product name
- EX-527 R
- Packaging
- 100mg
- Price
- $1423
- Updated
- 2021/12/16
AK Scientific
- Product number
- 2932AH
- Product name
- (R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
- Packaging
- 500mg
- Price
- $2317
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FE137671
- Product name
- EX 527(R)
- Packaging
- 10mg
- Price
- $175
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3575
- Product name
- SelisistatR-enantiomer
- Purity
- 98.69%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3575
- Product name
- SelisistatR-enantiomer
- Purity
- 98.69%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
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EX-527 (R-enantioMer) Chemical Properties,Usage,Production
Uses
(R)-Selisistat ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
Definition
ChEBI: (R)-selisistat is a 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has R configuration. It is the inactive enantiomer. It is an enantiomer of a (S)-selisistat.
References
[1] Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v
EX-527 (R-enantioMer) Preparation Products And Raw materials
Raw materials
Preparation Products
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EX-527 (R-enantioMer) Suppliers
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