ChemicalBook > CAS DataBase List > TAK-063
TAK-063
- Product Name
- TAK-063
- CAS No.
- 1238697-26-1
- Chemical Name
- TAK-063
- Synonyms
- CS-1534;TAK-063;Balipodect;TAK 063;TAK063;TAK-063(Balipodect);TAK063, TAK 063, TAK-063, BALIPODECT;1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one;4(1H)-Pyridazinone, 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-; Pyridone 6[1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one]
- CBNumber
- CB62735539
- Molecular Formula
- C23H17FN6O2
- Formula Weight
- 428.42
- MOL File
- 1238697-26-1.mol
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TAK-063 Property
- Boiling point:
- 612.3±65.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:55.0(Max Conc. mg/mL);128.38(Max Conc. mM)
- form
- A crystalline solid
- pka
- -0.34±0.12(Predicted)
- color
- Light yellow to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 22208
- Product name
- TAK-063
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22208
- Product name
- TAK-063
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $135
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22208
- Product name
- TAK-063
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $212
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22208
- Product name
- TAK-063
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $336
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-3551
- Product name
- Balipodect
- Purity
- 98.69%
- Packaging
- 5mg
- Price
- $84
- Updated
- 2021/12/16
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TAK-063 Chemical Properties,Usage,Production
Description
TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A; IC50 = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits <50% inhibition at 91 receptors, ion channels, and enzymes at a concentration of 10 μM. TAK-063 (0.3 mg/kg) increases cAMP and cGMP levels by 1.3- and 2.14-fold, respectively, in the striatum of mice. It reverses hyperlocomotion induced by PCP (Item Nos. 14276 | ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063 also reverses hyperlocomotion induced by (+)-MK-801 (MED = 0.1 mg/kg, p.o.) but has no effect on plasma prolactin or glucose levels in rats.
TAK-063 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TAK-063 manufacturers
Career Henan Chemical Co
- Product
- Pyridone 6[1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] 1238697-26-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30