ChemicalBook > CAS DataBase List > 7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide

7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide

Product Name
7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide
CAS No.
1236199-60-2
Chemical Name
7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide
Synonyms
CS-2555;EDO-S101;Minomustine;Tinostamustine(EDO-S101);EDO-S101;EDO S101;EDOS101;EDO-S101?(Tinostamustine);Histone deacetylases,Inhibitor,EDO-S101,EDOS101,inhibit,EDO S101,HDAC,EDO-S-101;1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-;7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}-N-hydroxyheptanamide;7-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide
CBNumber
CB62735711
Molecular Formula
C19H28Cl2N4O2
Formula Weight
415.36
MOL File
1236199-60-2.mol
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7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Property

Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO:14.0(Max Conc. mg/mL);33.71(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.82(Max Conc. mM)
form 
A crystalline solid
pka
9.48±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23328
Product name
EDO-S101
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
23328
Product name
EDO-S101
Purity
≥98%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
23328
Product name
EDO-S101
Purity
≥98%
Packaging
10mg
Price
$632
Updated
2024/03/01
Cayman Chemical
Product number
23328
Product name
EDO-S101
Purity
≥98%
Packaging
25mg
Price
$1184
Updated
2024/03/01
AK Scientific
Product number
8336DG
Product name
Tinostamustine
Packaging
25mg
Price
$1416
Updated
2021/12/16
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7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Chemical Properties,Usage,Production

Description

EDO-S101 is a fusion molecule composed of the DNA alkylating agent bendamustine and the histone deacetylase (HDAC) inhibitor SAHA that inhibits class I and II HDACs (IC50s = 9-107 nM for HDAC1-3, 6, 8, and 10). It inhibits HDAC activity in rat peripheral blood mononuclear cells (PBMCs) ex vivo by 90% following a single dose of 10 mg/kg. EDO-S101 also induces formation of DNA crosslinks and double-strand breaks in HL-60 cells. It reduces growth of multiple myeloma (MM) cell lines irrespective of p53 mutational status or established resistance to DNA alkylating agents (IC50s = 1.6-4.8 μM). EDO-S101 also induces MM cell death ex vivo in bone marrow samples isolated from patients with early- and late-stage MM. In vivo, EDO-S101 (60 mg/kg per week) reduces tumor growth and prolongs survival in an MM1S end-stage mouse xenograft model. It also prolongs survival in a multidrug resistant Vk12653 mouse transplant model of refractory MM.

7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Suppliers

China 46 United States 5 USA 1 Global 52
Acesys Pharmatech
Tel
18860950986
Email
tangmanman@zenjipharma.com
Country
China
ProdList
1733
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4573
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55
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q2816483246
Fax
QQ3382968513
Email
danping@shsendpharm.com
Country
China
ProdList
3096
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
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Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2992
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58
Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 4009686088
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3193328036@qq.com
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China
ProdList
29785
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68
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
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China
ProdList
12306
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58
Chuzhou KeMail Chemical Technology Co., Ltd
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0550-5196001 15000891977
Fax
0550-5196001
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wj520wjxby@126.com
Country
China
ProdList
1925
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55
Twochem Co.Ltd.
Tel
021-58111628 15800915896
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QQ 3285589261
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sales@twochem.com
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China
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1788
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Yujinpharma(Tianjin) Technology Co.,Ltd.
Tel
13370351217 kungfu1217@1
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QQ1400885609
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kungfu1217@163.com
Country
China
ProdList
8982
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58

1236199-60-2, 7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMideRelated Search:


  • Tinostamustine(EDO-S101)
  • CS-2555
  • EDO-S101;EDO S101;EDOS101
  • 7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide
  • EDO-S101
  • Minomustine
  • 7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}-N-hydroxyheptanamide
  • 7-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide
  • 1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-
  • Histone deacetylases,Inhibitor,EDO-S101,EDOS101,inhibit,EDO S101,HDAC,EDO-S-101
  • EDO-S101?(Tinostamustine)
  • 1236199-60-2