3-BroMo-2,6-dichloro-1-Methylbenzene
- Product Name
- 3-BroMo-2,6-dichloro-1-Methylbenzene
- CAS No.
- 127049-87-0
- Chemical Name
- 3-BroMo-2,6-dichloro-1-Methylbenzene
- Synonyms
- 1-bromo-2,4-dichloro-3-methylbenzene;3-BroMo-2,6-dichloro-1-Methylbenzene;Benzene, 1-bromo-2,4-dichloro-3-methyl-
- CBNumber
- CB62736389
- Molecular Formula
- C7H5BrCl2
- Formula Weight
- 239.92
- MOL File
- 127049-87-0.mol
3-BroMo-2,6-dichloro-1-Methylbenzene Property
- Boiling point:
- 258.0±35.0 °C(Predicted)
- Density
- 1.645±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B683230
- Product name
- 1-Bromo-2,4-dichloro-3-methylbenzene
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 409164
- Product name
- 1-Bromo-2,4-dichloro-3-methylbenzene
- Packaging
- 100mg
- Price
- $326
- Updated
- 2021/12/16
- Product number
- X6472
- Product name
- 1-Bromo-2,4-dichloro-3-methylbenzene
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- J97353
- Product name
- 1-Bromo-2,4-dichloro-3-methylbenzene
- Packaging
- 5g
- Price
- $328
- Updated
- 2021/12/16
- Product number
- HCH0356770
- Product name
- 1-BROMO-2,4-DICHLORO-3-METHYLBENZENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.62
- Updated
- 2021/12/16
3-BroMo-2,6-dichloro-1-Methylbenzene Chemical Properties,Usage,Production
Uses
1-Bromo-2,4-dichloro-3-methylbenzene is an intermediate used to prepare cycloalkyl lactam derivatives as 11β-HSD1 inhibitors.
Synthesis
118-69-4
127049-87-0
The general procedure for the synthesis of 2,6-dichloro-3-bromotoluene from 2,6-dichlorotoluene was as follows: 2,6-dichlorotoluene (50.0 g, 0.31 mol), iodine (0.10 g, 0.39 mmol), and 325-mesh iron powder (0.70 g, 12.5 mmol) were dissolved in carbon tetrachloride (60 mL), and bromine (52.8 g, 0.33 mol) was added slowly dropwise. mol), and the dropwise addition process was controlled to be completed within 20 min. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was poured into ice water and extracted with 1,2-dichloroethane. The organic layer was washed with saturated sodium bisulfite solution and dried with anhydrous sodium sulfate. Finally, the solvent was removed by distillation under reduced pressure to give 1-bromo-2,4-dichloro-3-methylbenzene (76.01 g, 100% yield).
References
[1] Patent: US2009/111800, 2009, A1. Location in patent: Page/Page column 38
3-BroMo-2,6-dichloro-1-Methylbenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BroMo-2,6-dichloro-1-Methylbenzene manufacturers
- Product
- 1-Bromo-2,4-dichloro-3-methylbenzene 127049-87-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-29