Methyl 3-(4-Iodophenyl)propanoate
- Product Name
- Methyl 3-(4-Iodophenyl)propanoate
- CAS No.
- 33994-44-4
- Chemical Name
- Methyl 3-(4-Iodophenyl)propanoate
- Synonyms
- Methyl 3-(4-Iodophenyl)propanoate;3-(4-iodophenyl)propionic acid methyl ester;Benzenepropanoic acid, 4-iodo-, methyl ester
- CBNumber
- CB62736460
- Molecular Formula
- C10H11IO2
- Formula Weight
- 290.1
- MOL File
- 33994-44-4.mol
Methyl 3-(4-Iodophenyl)propanoate Property
- storage temp.
- 2-8°C(protect from light)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C10H11IO2/c1-13-10(12)7-4-8-2-5-9(11)6-3-8/h2-3,5-6H,4,7H2,1H3
- InChIKey
- LDCXVBUZHUHPAJ-UHFFFAOYSA-N
- SMILES
- C1(CCC(OC)=O)=CC=C(I)C=C1
N-Bromosuccinimide Price
- Product number
- M313708
- Product name
- Methyl3-(4-Iodophenyl)propanoate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 6984AJ
- Product name
- Methyl3-(4-iodophenyl)propanoate
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
- Product number
- A276800
- Product name
- Methyl3-(4-Iodophenyl)propanoate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- A276800
- Product name
- Methyl3-(4-Iodophenyl)propanoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- CD12081677
- Product name
- Methyl3-(4-Iodophenyl)propanoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $274
- Updated
- 2021/12/16
Methyl 3-(4-Iodophenyl)propanoate Chemical Properties,Usage,Production
Uses
Methyl 3-(4-Iodophenyl)propanoate is used as a reactant in the preparation of HKGreen-1, a highly selective fluorescent probe for the detection of peroxynitrite in living cells.
Synthesis
67-56-1
1643-29-4
33994-44-4
Methanol (5 mL) was cooled to 0°C under nitrogen protection and acetyl chloride (0.4 mL, 5.63 mmol) was added slowly and dropwise. After stirring the reaction for 10 min, 3-(4-iodophenyl)propionic acid (498 mg, 1.80 mmol) was slowly added. The reaction mixture was stirred at room temperature for VA h and subsequently concentrated under vacuum. The concentrate was redissolved in methanol and concentrated again to give 512 mg (98% yield) of pure white solid product methyl 3-(4-iodophenyl)propionate. Thin layer chromatography (TLC) Rf value was 0.39 (unfolding agent ratio: ethyl acetate:hexane = 1:4). Nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) δ 7.61-7.59 (m, 2H), 6.97-6.94 (m, 2H), 3.66 (s, 3H), 2.92-2.87 (t, 2H, J=7.5 Hz), 2.63-2.58 (t, 2H, J=7.5 Hz). Nuclear magnetic resonance carbon spectrum (13C NMR, CDCl3) δ 173.0, 140.1, 137.5, 130.4, 91.4, 51.7, 35.4, 30.4. electron bombardment mass spectrum (EI-MS) m/z 290.0 (MH+).
References
[1] Organic Letters, 2008, vol. 10, # 12, p. 2597 - 2600
[2] Patent: WO2009/137322, 2009, A2. Location in patent: Page/Page column 15
[3] Journal of the American Chemical Society, 2009, vol. 131, # 47, p. 17500 - 17521
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 22, p. 7061 - 7064
[5] Patent: WO2010/12650, 2010, A1. Location in patent: Page/Page column 39
Methyl 3-(4-Iodophenyl)propanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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