Velpatasvir

ChemicalBook > CAS DataBase List > Velpatasvir

Product Name: Velpatasvir
CAS No.: 1377049-84-7
Chemical Name: Velpatasvir
Synonyms: GS 5816;CS-2204;Vipatavir;Vipataivir;Velpatasvir;MFCD28411371;Velpatasvir API;GS 5816;GS-5816;Velpatasvir(PVP);Unifiram (DM-232)
CBNumber: CB62743053
Molecular Formula: C49H54N8O8
Formula Weight: 883
MOL File: 1377049-84-7.mol

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Velpatasvir Property

Melting point:: >170oC (dec.)
Density: 1.314±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 10.75±0.46(Predicted)
color: Pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H413May cause long lasting harmful effects to aquatic life

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21280
Product name: Velpatasvir
Purity: ≥98%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21280
Product name: Velpatasvir
Purity: ≥98%
Packaging: 50mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 21280
Product name: Velpatasvir
Purity: ≥98%
Packaging: 100mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 21280
Product name: Velpatasvir
Purity: ≥98%
Packaging: 250mg
Price: $298
Updated: 2024/03/01

TRC

Product number: V116000
Product name: Velpatasvir
Packaging: 500mg
Price: $470
Updated: 2021/12/16

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Velpatasvir Chemical Properties,Usage,Production

Description

Velpatasvir (1377049-84-7) is an extremely potent pan-genotypic hepatitis C virus (HCV) NS5A inhibitor.1 It is a component of Epclusa? and Vosevi?, two clinically useful medications with 98% and 97%, respectively, cure rates for HCV.? It displayed EC50’s for GTs 1-4, 6a ranging from 6-16 pM, GT5a at 75 pM, and GT6e at 130 pM. Velpatasvir also displayed an excellent barrier to viral resistance. It has been shown in silico, that velpatasvir binds to the SARS-CoV-2 spike protein and may be a potential therapeutic.2

Uses

Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Definition

ChEBI: Velpatasvir is a complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes. It has a role as an antiviral drug and a hepatitis C virus nonstructural protein 5A inhibitor. It is an organic heteropentacyclic compound, a N-acylpyrrolidine, a L-valine derivative, a carbamate ester, a member of imidazoles, a ring assembly and an ether.

brand name

Epclusa, Sofosvel, Velpanat (all in combination with sofosbuvir)

References

Link et al. (2019), Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi? and Epclusa?; Bioorg. Med. Chem. Lett., 29 2415 Kadioglu et al. (2020), Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning; Comput. Biol. Med. 133 104359

Velpatasvir Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Velpatasvir manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Velpatasvir 1377049-84-7
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%-102%
Supply Ability: 10 KGS
Release date: 2021-06-16

shandong perfect biotechnology co.ltd

Product: Velpatasvir(PVP) 1377049-84-7
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2023-08-14

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Velpatasvir 1377049-84-7
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-04

1377049-84-7, VelpatasvirRelated Search:

(S)-1-tert-Butyl 5-methyl 2-((tert-butoxycarbonyl)amino)pentanedioate ZANAMIVIR HYDRATE Dutasteride Tacrolimus Zofenopril calcium Sofosbuvir Rituximab Levofloxacin hydrochloride (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER Velpatasvir intermediate Velpatasvir intermediate Velpatasvir intermediate (R)-2-(methoxycarbonylamino)-2-phenylacetic acid Velpatasvir Co Povidone Velpatasvir intermediate (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid BOC-L-PYROGLUTAMIC ACID BENZYL ESTER

Velpatasvir

GS 5816

velpatasvir(GS-5816)

methyl ((2s)-1-((2s,5s)-2-(9-(2-((2s,4s)-1-((2r)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-4-(methoxymethyl)pyrrolidin-2-yl)-1h-imidazol-5-yl)-1,11-dihydroisochromeno(4',3':6,7)naphtho(1,2-d)imidazol-2-yl)-5-methylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Velpatasvir API

Unifiram (DM-232)

GS 5816;GS-5816

CS-2204

Velpatasvir (Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[4-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H- imidazol-2-yl]-4-(methoxymethyl)-1-pyrrol

Methyl [(2S)-1-[(2S,5S)-2-[9-[2-[(2S,4S)-1-[(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-y

MFCD28411371

Product:Velpatasvir

Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-

Velpatasvir intermediate A13

Velpatasvir (10mM in DMSO)

GS-5816(Velpatasvir)

TIANFU CHEM Velpatasvir

Velpatasvir(PVP)

Velpatasvir inteVelpatasvir intermediate A13rmediate A13

Vipataivir

N-(1R)-2-(2S,4S)-2-5-1,11-Dihydro-2-(2S,5S)-1-(2S)-2-(methoxycarbonyl)amino-3-methyl-1-oxo-butyl-5-methylpyrrolidin-2-yl2benzopyrano4',3':6,7naphtho1,2-dimidazol-9-yl-1H-imidazol-2-yl-4-(methoxymethyl)-pyrrolidin-1-yl-2-oxo-1-phenylethylcarbamic acid methyl ester

Vipatavir

Methyl ((2S)-1-((2S,5S)-2-(9-(2-((2S,4S)-1-((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-4-(methoxymethyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4′,3′:6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-, methyl ester (ACI)

1377049-84-7

377049-84-7

C49H54N8O8

1377049-84-7