TAI-1

Product Name: TAI-1
CAS No.: 1334921-03-7
Chemical Name: TAI-1
Synonyms: TAI 1;TAI1;TAI-1 USP/EP/BP;TAI-1, 10 mM in DMSO;TAI 1,TAI1,inhibit,Inhibitor,Apoptosis,TAI-1;N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide;4-Pyridinecarboxamide, N-[4-[4-(4-methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]-
CBNumber: CB62744616
Molecular Formula: C24H21N3O3S
Formula Weight: 431.51
MOL File: 1334921-03-7.mol

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TAI-1 Property

Density: 1.281±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥43.2 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH
form: solid
pka: 5.38±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B4892
Product name: TAI-1
Packaging: 5mg
Price: $124
Updated: 2021/12/16

ApexBio Technology

Product number: B4892
Product name: TAI-1
Packaging: 25mg
Price: $401
Updated: 2021/12/16

ApexBio Technology

Product number: B4892
Product name: TAI-1
Packaging: 100mg
Price: $838
Updated: 2021/12/16

DC Chemicals

Product number: DC8148
Product name: TAI-1
Purity: >98%
Packaging: 1g
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC8148
Product name: TAI-1
Purity: >98%
Packaging: 250mg
Price: $800
Updated: 2021/12/16

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TAI-1 Chemical Properties,Usage,Production

Uses

TAI-1, an orally active anticancer agent, is a highly potent first-in-class Hec1 inhibitor, with a GI50 of 13.48 nM in K562 cells[1].

in vivo

TAI-1 (20 mg/kg intravenously IV/ or 150 mg/kg per oral PO/BID) inhibits tumor growth in multiple cancer xenograft models^[1].

Animal Model:	C.B-17 SCID mice (6-7 weeks, 21-24 g)^[1].
Dosage:	20 mg/kg intravenously IV/ or 150 mg/kg per oral PO/BID.
Administration:	QDx28 cycles.
Result:	Led to significant tumor growth retardation in Huh-7 and modest tumor inhibition was noted tor the Colo205 and MDA-MB-231 models. Did not lead to any loss in body weight.

IC 50

NEK2

References

[1] Lynn Y L Huang, et al. Characterization of the Biological Activity of a Potent Small Molecule Hec1 Inhibitor TAI-1. J Exp Clin Cancer Res. 2014 Jan 9;33(1):6. DOI:10.1186/1756-9966-33-6

TAI-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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TAI-1 Suppliers

China 35 United States 6 Global 41

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
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Hangzhou ChangCun Biotechnology Co., Ltd.

Tel: 0571-; 13567100326
Fax: QQ158848739
Email: 158848739@qq.com
Country: China
ProdList: 108
Advantage: 50

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3277
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
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Country: United States
ProdList: 6391
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

1334921-03-7, TAI-1Related Search:

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N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

TAI 1;TAI1

4-Pyridinecarboxamide, N-[4-[4-(4-methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]-

TAI-1 USP/EP/BP

TAI 1,TAI1,inhibit,Inhibitor,Apoptosis,TAI-1

TAI-1, 10 mM in DMSO

1334921-03-7

Inhibitors