ChemicalBook > CAS DataBase List > ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate

ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate

Product Name
ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate
CAS No.
1137359-47-7
Chemical Name
ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate
Synonyms
CS-1560;BRD7552;BRD-7552 (BRD7552;BRD7552 >=98% (HPLC);BRD7552, 10 mM in DMSO;BRD 7552;BRD-7552;BRD7552;Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside;α-D-Glucopyranoside, methyl, 2,3-bis(N-1,3-benzodioxol-5-ylcarbamate) 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate];promoter,BRD-7552,islets,human,inhibit,epigenetic,ductal,changes,insulin,BRD 7552,BRD7552,primary,Inhibitor,cells;ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate
CBNumber
CB62744621
Molecular Formula
C33H33N3O15
Formula Weight
711.63
MOL File
1137359-47-7.mol
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ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate Property

Boiling point:
757.6±60.0 °C(Predicted)
Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
pka
11.81±0.20(Predicted)
color 
White to off-white
InChIKey
WCJITTLHDWXESU-PSUBRWEKNA-N
SMILES
C(OCC)(=O)C1=CC=C(C(O[C@H]2[C@H](OC(=O)NC3C=C4C(=CC=3)OCO4)[C@@H](OC(=O)NC3C=C4C(=CC=3)OCO4)[C@@H](OC)O[C@@H]2CO)=O)C=C1 |&1:11,12,26,40,44,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19143
Product name
BRD7552
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19143
Product name
BRD7552
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
19143
Product name
BRD7552
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
19143
Product name
BRD7552
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
B677678
Product name
BRD7552
Packaging
25mg
Price
$470
Updated
2021/12/16
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ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate Chemical Properties,Usage,Production

Description

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as PDX1 protein levels, in PANC-1 cells. It also increases acetylation of histone H3 and trimethylation of H3K4 and H3K9.

Uses

BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells.

References

[1] YUAN YUAN. A small-molecule inducer of PDX1 expression identified by high-throughput screening.[J]. Chemistry & biology, 2013, 20 12: 1513-1522. DOI: 10.1016/j.chembiol.2013.10.013

ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate Suppliers

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1137359-47-7, ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoateRelated Search:


  • ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate
  • BRD7552
  • CS-1560
  • BRD 7552;BRD-7552;BRD7552
  • Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside
  • α-D-Glucopyranoside, methyl, 2,3-bis(N-1,3-benzodioxol-5-ylcarbamate) 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate]
  • BRD7552 >=98% (HPLC)
  • Ethyl 4-(((((2R,3R,4S,5R,6S)-4,5-bis((benzo[d][1,3]dioxol-5-ylcarbamoyl)oxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)carbonyl)amino)benzoate
  • promoter,BRD-7552,islets,human,inhibit,epigenetic,ductal,changes,insulin,BRD 7552,BRD7552,primary,Inhibitor,cells
  • BRD7552, 10 mM in DMSO
  • BRD-7552 (BRD7552
  • 1137359-47-7
  • C33H33N3O15