ChemicalBook > CAS DataBase List > TP0903
TP0903
- Product Name
- TP0903
- CAS No.
- 1341200-45-0
- Chemical Name
- TP0903
- Synonyms
- TP0903;TP-0903;CS-1642;Dubermatinib;Apraclonidina;TP 0903;TP0903;Apraclonidinum;Dubermatinib(TP-0903);TP-0903(Dubermatinib);2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
- CBNumber
- CB62745451
- Molecular Formula
- C24H30ClN7O2S
- Formula Weight
- 516.06
- MOL File
- 1341200-45-0.mol
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TP0903 Property
- Melting point:
- >198°C (dec.)
- Boiling point:
- 664.7±65.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 7.60±0.10(Predicted)
- form
- Solid
- color
- Off-White to Light Yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 28757
- Product name
- TP-0903
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28757
- Product name
- TP-0903
- Packaging
- 25mg
- Price
- $593
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28757
- Product name
- TP-0903
- Packaging
- 5mg
- Price
- $152
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28757
- Product name
- TP-0903
- Packaging
- 10mg
- Price
- $270
- Updated
- 2024/03/01
TRC
- Product number
- T700300
- Product name
- TP-0903
- Packaging
- 2.5mg
- Price
- $55
- Updated
- 2021/12/16
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TP0903 Chemical Properties,Usage,Production
Uses
TP-0903 is an AXL kinase inhibitor.
Biological Activity
axl and other tam family members are known to be involved in maintaining the mesenchymal phenotype in cancer cells. mesenchymal cells have increased invasion and migratory properties, enhanced cell survival in stressed environments, as well as increased resistance to targeted therapies. tp-0903 is a potent anti-cancer agent targeting the axl receptor tyrosine kinase.
in vitro
on the basis of the potency of tp-0903 in biochemical assays, its activity in cell-based studies was evaluated. tp-0903 showed extremely potent activity in cell viability assays against the pancreatic cancer cell line psn-1. more importantly, tp-0903 was evaluated for its ability to block gas6-mediated activation of axl in pancreatic cancer cells. psn-1 cells were serum-starved and then stimulated with gas6 in the presence of various concentrations of tp-0903 [1].
in vivo
tp-0903 restores sensitivity to erlotinib in cell-based and preclinical animal models of cancer by reversing the mesenchymal phenotype driving resistance [2].
IC 50
0.027 μm against axl
References
[1] mollard a, warner sl, call lt, wade ml, bearss jj, verma a, sharma s, vankayalapati h, bearss dj. design, synthesis and biological evaluation of a series of novel axl kinase inhibitors. acs med chem lett. 2011 dec 8;2(12):907-912.
[2] toleropharmaceuticals, inc–tp-0903. http://www.toleropharmaceuticals.com/tp-0903.html.
TP0903 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TP0903 manufacturers
Career Henan Chemical Co
- Product
- 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide 1341200-45-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30