(2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Product Name: (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.: 114676-61-8
Chemical Name: (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Synonyms: (2S,4R)-1-Boc-4-hydroxy-2-methylpyrrolidine;(2S,4R)-N-Boc-2-methyl-4-hydroxy-prrolidine;(2R,4R)-N-Boc-2-methyl-4-hydroxy-pyrrolidine;(2S,4R)-1-Boc--4-Hydroxy-2-methylpyrrolidine ee;tert-Butyl (2S,4R)-4-Hydroxy-2-methylpyrrolidine-1-carboxylic;(2S,4R)-tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate;tert-butyl (2s,4r)-4-hydroxy-2-methylpyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-methyl-, 1,1-dimet...;(2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-methyl-, 1,1-dimethylethyl ester, (2S,4R)-
CBNumber: CB62745613
Molecular Formula: C10H19NO3
Formula Weight: 201.26
MOL File: 114676-61-8.mol

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(2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Property

Melting point:: 75-78 °C
Boiling point:: 282.5±33.0 °C(Predicted)
Density: 1.094±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.75±0.40(Predicted)
Appearance: White to yellow Solid
optical activity: 20.6°(C=0.01g/100mL, DCM, 20°C, 589nm)
InChI: InChI=1S/C10H19NO3/c1-7-5-8(12)6-11(7)9(13)14-10(2,3)4/h7-8,12H,5-6H2,1-4H3/t7-,8+/m0/s1
InChIKey: BXZADLGAYWRZCR-JGVFFNPUSA-N
SMILES: N1(C(OC(C)(C)C)=O)C[C@H](O)C[C@@H]1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

AK Scientific

Product number: 8581AH
Product name: (2S,4R)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate
Packaging: 250mg
Price: $251
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-642
Product name: tert-Butyl (2S,4R)-4-hydroxy-2-methylpyrrolidine-1-carboxylate
Purity: 97.0%
Packaging: 250mg
Price: $390
Updated: 2021/12/16

Ambeed

Product number: A311614
Product name: (2S,4R)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate
Purity: 95%
Packaging: 100mg
Price: $59
Updated: 2021/12/16

Crysdot

Product number: CD11346750
Product name: (2S,4R)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $87
Updated: 2021/12/16

Ambeed

Product number: A311614
Product name: (2S,4R)-tert-Butyl4-hydroxy-2-methylpyrrolidine-1-carboxylate
Purity: 95%
Packaging: 250mg
Price: $88
Updated: 2021/12/16

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(2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

213699-41-3

114676-61-8

Tert-butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-methylpyrrolidine-1-carboxylate (2.2 g, 6.98 mmol) was dissolved in tetrahydrofuran (30 mL), followed by addition of tetrabutylammonium fluoride (3.65 g, 14.0 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was poured into water (60 mL) and extracted with ethyl acetate (60 mL x 2). The organic phases were combined, washed with saturated sodium chloride solution (60 mL x 2) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by column chromatography (petroleum ether: ethyl acetate = 2:1) to give 1.47 g of a yellow oily product, i.e. tert-butyl (2S,4R)-4-hydroxy-2-methylpyrrolidine-1-carboxylate in 99% yield.

References

[1] Patent: EP3401315, 2018, A1. Location in patent: Paragraph 0106; 0111
[2] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
[3] Journal of the American Chemical Society, 2008, vol. 130, # 3, p. 875 - 886

(2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester Suppliers

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View Lastest Price from (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester manufacturers

Career Henan Chemical Co

Product: (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 114676-61-8
Price: US $0.01/KG
Min. Order: 500g
Purity: 98%; 99%
Supply Ability: 500g；1kg； 10kg; 25kg
Release date: 2020-01-08

114676-61-8, (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl esterRelated Search:

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(2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

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114676-61-8