3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
- Product Name
- 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
- CAS No.
- 1031206-36-6
- Chemical Name
- 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
- Synonyms
- IMS2186;IMS2186, 10 mM in DMSO;(E)-3-(3-Hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one;3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one;(3E)-2,3-Dihydro-3-[(3-Hydroxy-4-Methoxyphenyl)Methylene]-6-Methyl-4H-1-Benzopyran-4-One;4H-1-Benzopyran-4-one, 2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-, (3E)-
- CBNumber
- CB62750358
- Molecular Formula
- C18H16O4
- Formula Weight
- 296.32
- MOL File
- 1031206-36-6.mol
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one Property
- Boiling point:
- 535.7±50.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: >20mg/mL
- pka
- 9.39±0.10(Predicted)
- form
- solid
- color
- white to off-white
N-Bromosuccinimide Price
- Product number
- I7160
- Product name
- IMS2186
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $77.7
- Updated
- 2025/07/31
- Product number
- I268653
- Product name
- IMS2186
- Packaging
- 10mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 452283
- Product name
- IMS2186
- Packaging
- 5mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- INB0000992
- Product name
- IMS2186
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $481
- Updated
- 2021/12/16
- Product number
- INB0000992
- Product name
- IMS2186
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $537.6
- Updated
- 2021/12/16
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one Chemical Properties,Usage,Production
Uses
IMS2186 is an anti-prileferative and anti-angiogenic compound.
Biological Activity
IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.
in vivo
IMS2186 (2.5 mg in 0.5 mL; intravitreal injection; single dose) has no ocular toxicity while applied to rabbit eyes[1].
IMS2186 (100 μg/eye, i.e. 2.0 μL of the solution of 50 μg/μL; single dose) shows anti-proliferative effect on laser-induced choroidal neovascularization (CNV) rat models[1].
| Animal Model: | Rat model of laser induced CNV[1] |
| Dosage: | 100 μg/eye, 2.0 μL of the solution of 50 μg/μL |
| Administration: | Intravitreal injection; single dose |
| Result: | Resulted 30% reduction of lesion area compared to PBS in the lesion area measurement. |