2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide
- Product Name
- 2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide
- CAS No.
- 901751-47-1
- Chemical Name
- 2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide
- Synonyms
- iCRT3;CS-2716;ICRT3;ICRT-3;ICRT 3;Inhibitor,Wnt,Apoptosis,inhibit,iCRT-3,iCRT3,iCRT 3;2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide;Acetamide, 2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)-
- CBNumber
- CB62750484
- Molecular Formula
- C23H26N2O2S
- Formula Weight
- 394.53
- MOL File
- 901751-47-1.mol
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Property
- Density
- 1.150±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL
- form
- powder
- pka
- 14.62±0.46(Predicted)
- color
- white to tan
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0211
- Product name
- iCRT3
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- SML0211
- Product name
- iCRT3
- Packaging
- 25mg
- Price
- $309
- Updated
- 2024/03/01
- Product number
- I163905
- Product name
- iCRT3
- Packaging
- 10mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-0033387
- Product name
- iCRT3
- Purity
- 99.42%
- Packaging
- 50mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0033387
- Product name
- iCRT3
- Purity
- 99.42%
- Packaging
- 10mg
- Price
- $130
- Updated
- 2021/12/16
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Chemical Properties,Usage,Production
Uses
iCRT3, is an inhibitor of both Wnt and β-catenin-responsive transcription (CRT).
Uses
iCRT3 has been used:
- for β- catenin inhibition in dual luciferase assay
- to inhibit β-catenin /TCF interactions and their transcriptional activity
- as wingless/tailess (wnt) antagonist, to determine Wnt/β-catenin signaling is essential for PROX1-mediated regulation of forkhead box protein C2 (FOXC2)(3)catenin inhibition in dual luciferase assay
- to inhibit β- catenin /TCF interactions and their transcriptional activity
- as wingless/tailess (wnt) antagonist, to determine Wnt/β-catenin signaling is essential for PROX1-mediated regulation of forkhead box protein C2 (FOXC2)
General Description
iCRT3 is a small cell-permeable oxazole compound. It blocks cytokine secretion in lipopolysaccharide (LPS)-stimulated macrophages.
Biochem/physiol Actions
The key mediator of Wnt signaling is the transcriptional co-activator b-catenin. In the cytoplasm, b-catenin is tightly bound to a complex that includes Axin and GSK-3b. Stimulation causes b-catenin stabilization, translocation to the nucleus and association with TCF4 to initiate transcription of responsive genes, referred to as Catenin Responsive Transcription (CRT). Virtually all Wnt-associated cancers are the result of misregulated CRT. Three inhibitors of CRT (iCRT) were identified in a screen that employed RNAi based knockdown of Axin, which stimulates CRT without affecting upstream mechanisms such as GSK activity, transduction by disheveled / frizzled, etc. These compounds are potent inhibitors of CRT reporter genes, as well as endogenous gene targets. The compounds also disrupt b-catenin-TCF4 interaction in a dose dependent manner, and cause G0/G1 arrest in colon tumor lines.
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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