ChemicalBook > CAS DataBase List > 2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol

2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol

Product Name
2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
CAS No.
892686-59-8
Chemical Name
2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
Synonyms
BD750;BD750 >=98% (HPLC);BD750, 10 mM in DMSO;2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol;2-(2-Benzothiazoleyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol;2H-Indazol-3-ol, 2-(2-benzothiazolyl)-4,5,6,7-tetrahydro-;2-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol;Immunosuppressant,JAK,BD750,cell,Janus kinase,BD-750,inhibit,STAT,Inhibitor,BD 750
CBNumber
CB62750590
Molecular Formula
C14H13N3OS
Formula Weight
271.34
MOL File
892686-59-8.mol
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2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol Property

Boiling point:
509.4±60.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear (warmed)
form 
powder
pka
7.38±0.20(Predicted)
color 
white to light brown
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0129339
Product name
BD750
Purity
99.79%
Packaging
5mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0129339
Product name
BD750
Purity
99.79%
Packaging
10mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0129339
Product name
BD750
Purity
99.79%
Packaging
25mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0129339
Product name
BD750
Purity
99.79%
Packaging
50mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0129339
Product name
BD750
Purity
99.79%
Packaging
100mg
Price
$500
Updated
2021/12/16
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2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol Chemical Properties,Usage,Production

Uses

BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2].

in vivo

BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) in mice[2].

Animal Model:Female C57BL/6 mice (10 wks old, 19-21 g)[2].
Dosage:20 μM.
Administration:IV, treated DC on d 7, 11 and 15 post the first PTX injection (dpi 7, 11 and 15).
Result:Significantly reduced the frequency of Th1 and Th17 cells and increased the percentage of Tregs compared with mice receiving PBS.

IC 50

JAK3; STAT5

References

[1] Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168(3):632-43. DOI:10.1111/j.1476-5381.2012.02172.x
[2] Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214. DOI:10.2119/molmed.2016.00110

2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol Suppliers

China 35 Finland 1 United States 5 Global 41
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892686-59-8, 2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-olRelated Search:


  • BD750
  • 2-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
  • 2-(2-Benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
  • BD750 >=98% (HPLC)
  • Immunosuppressant,JAK,BD750,cell,Janus kinase,BD-750,inhibit,STAT,Inhibitor,BD 750
  • 2H-Indazol-3-ol, 2-(2-benzothiazolyl)-4,5,6,7-tetrahydro-
  • BD750, 10 mM in DMSO
  • 2-(2-Benzothiazoleyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
  • 892686-59-8