ChemicalBook > CAS DataBase List > 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride

6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride

Product Name
6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
CAS No.
789488-77-3
Chemical Name
6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
Synonyms
ENMD-1068;ENMD-1068 HCl;ENMD-1068 (ENMD1068);ENMD-1068 hydrochloride;ENMD1068 HCl,ENMD 1068 HCl;ENMD-1068 HCl, 10 mM in DMSO;6-amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one;ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist;1-Hexanone, 6-amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-;ENMD-1068 HCl|||ENMD 1068|||ENMD-1068|||ENMD1068|||ENMD-1068 hydrochloride
CBNumber
CB62750611
Molecular Formula
C15H29N3O2
Formula Weight
283.41
MOL File
789488-77-3.mol
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6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride Property

Boiling point:
478.7±40.0 °C(Predicted)
Density 
1.047±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: soluble25mg/mL, clear
form 
powder
pka
10.57±0.10(Predicted)
color 
white to beige
Water Solubility 
Water: 25 mg/mL，clear
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
46
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1039
Product name
ENMD-1068 hydrochloride
Purity
≥97% (HPLC)
Packaging
5mg
Price
$116.85
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1039
Product name
ENMD-1068 hydrochloride
Purity
≥97% (HPLC)
Packaging
25mg
Price
$489
Updated
2025/07/31
ChemScene
Product number
CS-0090095
Product name
ENMD-1068 hydrochloride
Purity
98.18%
Packaging
50mg
Price
$600
Updated
2021/12/16
AK Scientific
Product number
3785BB
Product name
6-Amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one
Packaging
500mg
Price
$628
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0121711
Product name
6-AMINO-1-[4-(3-METHYLBUTANOYL)PIPERAZIN-1-YL]HEXAN-1-ONE
Purity
95.00%
Packaging
1G
Price
$925.31
Updated
2021/12/16
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6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride Chemical Properties,Usage,Production

Uses

ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2).

Biochem/physiol Actions

ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice.

6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride Suppliers

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789488-77-3, 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochlorideRelated Search:

6,7-dichloro-2,3-dihydro-1-benzofuran-3-one 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE 6,7-DIMETHOXYCARBOSTYRIL 6-(3-chlorophenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione 6-amino-3-methyl-4(3H)-quinazolinone 6-[(2-Hydroxyethyl)sulfonyl]benzoxazol-2-(3H)one 6-(dimethylamino)-2,3-dihydro-1H-indole-2,3-dione 6-CHLORO[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-3(2H)-ONE 6-chlorohexan-3-one 6-AMino-1-Methyl-3,4-dihydroquinolin-2(1H)-one 6-Methoxy-3,4-dihydro-2H-1-benzothiin-4-one 6-Amino-1-cyclopropylmethyl-3,4-dihydro-1H-quinolin-2-one 6,7-difluoro-1,2-dihydroquinoxalin-2-one 6,7-DIFLUOROINDOLINE-2,3-DIONE 6-chloro-3,3-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one 6-hydroxyhexan-2-one 6-(aminomethyl)-1,2-dihydropyridin-2-one dihydrochloride 4(1H)-Pyrimidinone, 6-amino-5-methyl- (9CI)

  • 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
  • ENMD-1068 hydrochloride
  • ENMD-1068
  • ENMD-1068 (ENMD1068)
  • 6-amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one
  • ENMD-1068 HCl
  • ENMD1068 HCl,ENMD 1068 HCl
  • 1-Hexanone, 6-amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-
  • ENMD-1068 HCl|||ENMD 1068|||ENMD-1068|||ENMD1068|||ENMD-1068 hydrochloride
  • ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist
  • ENMD-1068 HCl, 10 mM in DMSO
  • 789488-77-3