ChemicalBook > CAS DataBase List > LGD-2226

LGD-2226

Product Name
LGD-2226
CAS No.
328947-93-9
Chemical Name
LGD-2226
Synonyms
LGD-2226;LGD-2226 (LGD2226);6-[Bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone;6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one;2(1H)-Quinolinone, 6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-
CBNumber
CB62750752
Molecular Formula
C14H9F9N2O
Formula Weight
392.22
MOL File
328947-93-9.mol
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LGD-2226 Property

Melting point:
187-190°C
Boiling point:
364.4±42.0 °C(Predicted)
Density 
1.526±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.88±0.70(Predicted)
color 
Pale Yellow to Light Yellow
BRN 
10716241
InChI
InChI=1S/C14H9F9N2O/c15-12(16,17)5-25(6-13(18,19)20)7-1-2-10-8(3-7)9(14(21,22)23)4-11(26)24-10/h1-4H,5-6H2,(H,24,26)
InChIKey
ULBPQWIGZUGPHU-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(N(CC(F)(F)F)CC(F)(F)F)C=C2)C(C(F)(F)F)=CC1=O
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Safety

Hazard Codes 
Xn
Risk Statements 
48/22
WGK Germany 
3
RTECS 
VC8275240
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
07682
Product name
6-[Bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone
Purity
analytical standard
Packaging
25mg
Price
$744
Updated
2024/03/01
TRC
Product number
L397615
Product name
LGD-2226
Packaging
5mg
Price
$110
Updated
2021/12/16
TRC
Product number
L397615
Product name
LGD-2226
Packaging
10mg
Price
$180
Updated
2021/12/16
TRC
Product number
L397615
Product name
LGD-2226
Packaging
100mg
Price
$1390
Updated
2021/12/16
DC Chemicals
Product number
DC22137
Product name
LGD2226
Purity
>98%
Packaging
1g
Price
$1600
Updated
2021/12/16
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LGD-2226 Chemical Properties,Usage,Production

Uses

LGD-2226 is an orally active potent and selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis. Show to have an anabolic effect on muscle and bone tissue.

Synthesis

A 2 L round flask, under argon, was charged with a solution of the 14.00 g amine( 6-Amino-4-trifluoromethylquinolin-2(1H)-one )in 350 ml trifluoroacetic acid. 5.80 g NaBH4 was added within 1 h. The mixture was stirred at room temperature for 16 h. After that 4.50 g NaBH4 was added and then heated to 70°C for 5 h. The heating bath was removed and it was stirred at room temperature over 2 d. In several portions water was carefully added. In total 1500 ml water was slowly added. The yellow-greenish precipitate was filtered and rinsed with water. After drying, the crude product was purified by column chromatography on silica gel by using hexane-ethyl acetate (1:4), followed by a recrystallization in chloroform. 18.1 g of LGD-2226 was obtained as a bright yellow solid (76%).

LGD-2226 Preparation Products And Raw materials

Raw materials

Preparation Products

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LGD-2226 Suppliers

ANHUI WITOP BIOTECH CO., LTD
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Zhejiang J&C Biological Technology Co.,Limited
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sales@sarms4muscle.com
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View Lastest Price from LGD-2226 manufacturers

Dorne Chemical Technology co. LTD
Product
LGD-2226 328947-93-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
hebei hongtan Biotechnology Co., Ltd
Product
LGD-2226 328947-93-9
Price
US $50.00-500.00/G
Min. Order
10G
Purity
98%
Supply Ability
2000KG
Release date
2024-06-06
Wuhan Senwayer Century Chemical Co.,Ltd
Product
LGD-2226 328947-93-9
Price
US $0.00/gram
Min. Order
1gram
Purity
99% HPLC
Supply Ability
20 tons
Release date
2022-12-08

328947-93-9, LGD-2226Related Search:


  • 6-[Bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone
  • LGD-2226
  • LGD-2226 (LGD2226)
  • 2(1H)-Quinolinone, 6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-
  • 6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
  • 328947-93-9