Methyl 4-chloro-3-fluoropicolinate
- Product Name
- Methyl 4-chloro-3-fluoropicolinate
- CAS No.
- 1034921-05-5
- Chemical Name
- Methyl 4-chloro-3-fluoropicolinate
- Synonyms
- Methyl 4-chloro-3-fluoropicolinate;Methyl 4-chloro-3-fluoropyridine-2-carboxylate;4-Chloro-3-fluoro-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 4-chloro-3-fluoro-, methyl ester
- CBNumber
- CB62756648
- Molecular Formula
- C7H5ClFNO2
- Formula Weight
- 189.57
- MOL File
- 1034921-05-5.mol
Methyl 4-chloro-3-fluoropicolinate Property
- Boiling point:
- 267.7±40.0 °C(Predicted)
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.72±0.10(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- M340550
- Product name
- Methyl4-Chloro-3-fluoropicolinate
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC421039
- Product name
- Methyl4-chloro-3-fluoropicolinate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- 3190DP
- Product name
- Methyl4-chloro-3-fluoropicolinate
- Packaging
- 1g
- Price
- $764
- Updated
- 2021/12/16
- Product number
- A122400
- Product name
- Methyl4-chloro-3-fluoropicolinate
- Purity
- 98%
- Packaging
- 100mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- A122400
- Product name
- Methyl4-chloro-3-fluoropicolinate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $205
- Updated
- 2021/12/16
Methyl 4-chloro-3-fluoropicolinate Chemical Properties,Usage,Production
Synthesis
67-56-1
1034921-07-7
1034921-05-5
A. The synthesis of methyl 4-chloro-3-fluoropyridinecarboxylate was carried out according to the literature method (see: Proc. Int., 29(1), 117-122 (1997)). The procedure was as follows: lithium 4-chloro-3-fluoropyridinecarboxylate (20.0 g, 136 mmol) and sodium bromide (28.0 g, 272 mmol, 2 eq.) were suspended in thionyl chloride (99 mL, 1.36 mol, 10 eq.), and the system was replaced by argon and heated to reflux (95°C). The reaction mixture was refluxed for 2 days, then thionyl chloride (50 mL, 680 mmol, 5 eq.) was added and refluxing was continued for 3 days. Upon completion of the reaction, the solvent was removed by evaporation and the residue was cooled to 0°C. Subsequently, methanol (300 mL) was added carefully in batches and the mixture was stirred overnight at 23°C. The reaction solution was diluted with ethyl acetate. The reaction solution was diluted with ethyl acetate and washed sequentially with saturated aqueous sodium carbonate solution and water, and the aqueous phase was then back-extracted with ethyl acetate. The organic layers were combined, dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was dissolved in boiling hexane and decanted to remove residual tar. The filtrate was evaporated to afford the target product methyl 4-chloro-3-fluoropyridinecarboxylate (24.36 g, 94% yield) as a solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 3.92 (3H, s), 8.01 (1H, t, J = 5.1 Hz), 8.50 (1H, d, J = 5.1 Hz). lC/MS (M + H)+: 190.
References
[1] Patent: US2010/48581, 2010, A1. Location in patent: Page/Page column 37
Methyl 4-chloro-3-fluoropicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
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