7-BROMO-5-NITRO-1H-INDAZOLE
- Product Name
- 7-BROMO-5-NITRO-1H-INDAZOLE
- CAS No.
- 685109-10-8
- Chemical Name
- 7-BROMO-5-NITRO-1H-INDAZOLE
- Synonyms
- 7-Bromo-5-nitroindazole;7-BROMO-5-NITRO-1H-INDAZOLE;1H-Indazole, 7-bromo-5-nitro-
- CBNumber
- CB6276366
- Molecular Formula
- C7H4BrN3O2
- Formula Weight
- 242.03
- MOL File
- Mol file
7-BROMO-5-NITRO-1H-INDAZOLE Property
- Melting point:
- 260-261°C
- Boiling point:
- 420.8±25.0 °C(Predicted)
- Density
- 1.965
- storage temp.
- 2-8°C
- pka
- 9.53±0.40(Predicted)
- Appearance
- Yellow to brown Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B677963
- Product name
- 7-Bromo-5-nitro-1H-indazole
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H54-9-X9
- Product name
- 7-Bromo-5-nitro-1H-indazole
- Packaging
- 500mg
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 4H54-9-X9
- Product name
- 7-Bromo-5-nitro-1H-indazole
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 043101
- Product name
- 7-Bromo-5-nitro-1H-indazole
- Purity
- >95%
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 043101
- Product name
- 7-Bromo-5-nitro-1H-indazole
- Purity
- >95%
- Packaging
- 1g
- Price
- $154
- Updated
- 2021/12/16
7-BROMO-5-NITRO-1H-INDAZOLE Chemical Properties,Usage,Production
Synthesis
102170-56-9
685109-10-8
General procedure for the synthesis of 7-bromo-5-nitro-1H-indazole from 2-bromo-6-methyl-4-nitroaniline: 2-bromo-6-methyl-4-nitroaniline (14.1 g, 61.0 mmol) was dissolved in glacial acetic acid (162 mL), and an aqueous solution of sodium nitrite (6.32 g, 91.5 mmol) was added slowly and dropwise (14 mL) under cooling in an ice bath. The dropwise addition time was controlled to be more than 10 min and the reaction temperature was kept below 25 °C. After the dropwise addition, the reaction mixture was stirred at 20 °C for 1 hour. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the residue was ground with a 1:1 methanol:water mixture, the precipitate was collected by filtration and dried at 80 °C for 6 h. 7-Bromo-5-nitro-1H-indazole (10.4 g, 49% yield) was obtained as a red solid. MS (ESI): calculated value C7H4BrN3O2 241.0, measured value m/z 242 [M + H] +. 1H NMR (300 MHz, DMSO-d6) δ 8.84 (s, 1H), 8.53 (s, 1H), 8.37 (s, 1H).
References
[1] Patent: WO2016/176460, 2016, A1. Location in patent: Page/Page column 97
[2] European Journal of Medicinal Chemistry, 2017, vol. 131, p. 1 - 13
7-BROMO-5-NITRO-1H-INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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