LORMETAZEPAM
- Product Name
- LORMETAZEPAM
- CAS No.
- 848-75-9
- Chemical Name
- LORMETAZEPAM
- Synonyms
- Loramet;WY-4082;Ergocalm;Noctamid;RO 5-5516;LORMETAZEPAM;lormethazepam;METHYLLORAZEPAM;N-Methyllorazepam;(RS)-Lormetazepam
- CBNumber
- CB6277893
- Molecular Formula
- C16H12Cl2N2O2
- Formula Weight
- 335.18
- MOL File
- 848-75-9.mol
LORMETAZEPAM Property
- Melting point:
- 163-168°C
- Boiling point:
- 575.8±50.0 °C(Predicted)
- Density
- 1.4463 (rough estimate)
- refractive index
- 1.6100 (estimate)
- Flash point:
- 9℃
- storage temp.
- Controlled Substance, -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 11.60±0.40(Predicted)
- color
- Pale Yellow to Pale Green
Safety
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25-22
- Safety Statements
- 7-16-36/37-45-36
- RIDADR
- 3249
- WGK Germany
- 1
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- L-907
- Product name
- Lormetazepam solution
- Purity
- 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $26.6
- Updated
- 2024/03/01
LORMETAZEPAM Chemical Properties,Usage,Production
Chemical Properties
Pale Green Solid
Originator
Loramet ,Wyeth, W. Germany,1980
Uses
An analog of Lorazepam (L469850). Sedative, hypnotic. Controlled substance (depressant).
Definition
ChEBI: Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.
Manufacturing Process
To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C.
Therapeutic Function
Hypnotic