5-(3-NITRO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE
- Product Name
- 5-(3-NITRO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE
- CAS No.
- 833-47-6
- Chemical Name
- 5-(3-NITRO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE
- Synonyms
- 5-(3-Nitrophenyl);TIMTEC-BB SBB007415;5-(3-NITROPHENYL)-1,3,4-THIADIAZOL-2-AMINE;2-AMINO-5-(3-NITROPHENYL)-1,3,4-THIADIAZOLE;1,3,4-Thiadiazol-2-amine, 5-(3-nitrophenyl)-;5-(3-NITRO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE;5-(3-Nitrophenyl)-1,3,4-thiadiazol-2-amine, 3-(5-Amino-1,3,4-thiadiazol-2-yl)nitrobenzene
- CBNumber
- CB6279024
- Molecular Formula
- C8H6N4O2S
- Formula Weight
- 222.22
- MOL File
- Mol file
5-(3-NITRO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE Property
- Melting point:
- 216-219 °C
- Boiling point:
- 445.0±47.0 °C(Predicted)
- Density
- 1.535±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.91±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- N498373
- Product name
- 5-(3-nitrophenyl)-1,3,4-thiadiazol-2-amine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- N498373
- Product name
- 5-(3-nitrophenyl)-1,3,4-thiadiazol-2-amine
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 007947
- Product name
- 5-(3-Nitrophenyl)[1,3,4]thiadiazol-2-ylamine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 007947
- Product name
- 5-(3-Nitrophenyl)[1,3,4]thiadiazol-2-ylamine
- Packaging
- 5g
- Price
- $295
- Updated
- 2021/12/16
- Product number
- 007947
- Product name
- 5-(3-Nitrophenyl)[1,3,4]thiadiazol-2-ylamine
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
5-(3-NITRO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE Chemical Properties,Usage,Production
Synthesis
5706-76-3
833-47-6
General methodology: In step 2, the Schiff base intermediate was dissolved in 1,4-dioxane, iodine and potassium carbonate were added, and the cyclization reaction was carried out at 80 °C. The reaction mixture was refluxed for 4 hours and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the addition of 5% sodium thiosulfate solution (20 mL). The target organic compound 5-(3-nitrophenyl)[1,3,4]thiadiazol-2-amine was extracted from the reaction mixture with ethyl acetate. The organic phase was collected and the solvent was removed by evaporation to give the target product 2-amino-1,3,4-thiadiazole derivative as a solid.
References
[1] Monatshefte fur Chemie, 2013, vol. 144, # 5, p. 681 - 686
[2] Bioorganic Chemistry, 2018, vol. 78, p. 201 - 209
[3] Farmaco, Edizione Scientifica, 1958, vol. 13, p. 187,196
[4] Indian Journal of Chemistry, 1970, vol. 8, p. 509 - 513
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 11, p. 3315 - 3320
5-(3-NITRO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE Preparation Products And Raw materials
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