1-(2,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE
- Product Name
- 1-(2,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE
- CAS No.
- 886371-22-8
- Chemical Name
- 1-(2,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE
- Synonyms
- 2',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE;1-(2,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE;Ethanone, 1-(2,5-dichlorophenyl)-2,2,2-trifluoro-
- CBNumber
- CB6284860
- Molecular Formula
- C8H3Cl2F3O
- Formula Weight
- 243.01
- MOL File
- 886371-22-8.mol
1-(2,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE Property
- Boiling point:
- 225.8±40.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4507AC
- Product name
- 1-(2,5-Dichlorophenyl)-2,2,2-trifluoroethanone
- Packaging
- 250mg
- Price
- $239
- Updated
- 2021/12/16
- Product number
- 6557
- Product name
- 2',5'-Dichloro-2,2,2-trifluoroacetophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 104053
- Product name
- 2',5'-Dichloro-2,2,2-trifluoroacetophenone
- Packaging
- 1g
- Price
- $359
- Updated
- 2021/12/16
- Product number
- 104053
- Product name
- 2',5'-Dichloro-2,2,2-trifluoroacetophenone
- Packaging
- 2g
- Price
- $513
- Updated
- 2021/12/16
- Product number
- 6557
- Product name
- 2',5'-Dichloro-2,2,2-trifluoroacetophenone
- Purity
- 97%
- Packaging
- 2g
- Price
- $516
- Updated
- 2021/12/16
1-(2,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE Chemical Properties,Usage,Production
Synthesis
106-46-7
431-47-0
886371-22-8
Example 1: Synthesis of 1-(2,5-dichlorophenyl)-2,2,2-trifluoroethanone 1,4-Dichlorobenzene (20 g, 136 mmol) was dissolved in anhydrous tetrahydrofuran (200 mL) and cooled to -78°C. With stirring, n-butyllithium (150 mmol, dissolved in 60 mL of hexane) was added slowly. The reaction mixture was stirred at -78°C for 1 hr. Subsequently, methyl trifluoroacetate (18 mL, 179 mmol) was added dropwise over 30 min. The reaction mixture was slowly warmed to 0°C and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of pre-cooled saturated aqueous ammonium chloride solution (100 mL). The organic and aqueous phases were separated. The organic phase was concentrated under reduced pressure and the residue was dissolved in ethyl acetate (200 mL). The aqueous phase was extracted once with ethyl acetate (200 mL). The organic phases were combined and washed with saturated saline (200 mL). The organic phase was separated, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with ethyl acetate/hexane (1/10, v/v) as eluent to give 1-(2,5-dichlorophenyl)-2,2,2-trifluoroacetophenone as an orange oil (28.5 g, 86% yield). 1H NMR (400 MHz, CDCl3) δ 7.67 (s, 1H), 7.56-7.50 (m, 2H).
References
[1] Patent: WO2012/79235, 2012, A1. Location in patent: Page/Page column 34
[2] Patent: WO2012/97511, 2012, A1. Location in patent: Page/Page column 57
[3] Patent: WO2012/97510, 2012, A1. Location in patent: Page/Page column 56
1-(2,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(2,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE manufacturers
- Product
- 1-(2,5-Dichlorophenyl)-2,2,2-trifluoroethanone 886371-22-8
- Price
- US $141.00-788.00/g
- Min. Order
- 1g
- Purity
- 0.97
- Supply Ability
- 25kg
- Release date
- 2023-12-08