6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
Uses- Product Name
- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
- CAS No.
- 914612-23-0
- Chemical Name
- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
- Synonyms
- CIVENTICHEM CV-5309;6-benzyl-4-chloro-5;6-Benzyl-4-chloro-5,6,7,8...;6-benzyl-4-chloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine;6-benzyl-4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine;-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE;6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE;Pyrido[4,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-6-(phenylmethyl)-;6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB6290209
- Molecular Formula
- C14H14ClN3
- Formula Weight
- 259.73
- MOL File
- 914612-23-0.mol
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Property
- Boiling point:
- 396.6±42.0 °C(Predicted)
- Density
- 1.273±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 5.01±0.20(Predicted)
- Appearance
- Light yellow to yellow Powder
- InChI
- InChI=1S/C14H14ClN3/c15-14-12-9-18(7-6-13(12)16-10-17-14)8-11-4-2-1-3-5-11/h1-5,10H,6-9H2
- InChIKey
- RPJAAZOTUXKSEV-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C2CN(CC3=CC=CC=C3)CCC2=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B233770
- Product name
- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- B233770
- Product name
- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
- Packaging
- 1g
- Price
- $780
- Updated
- 2021/12/16
- Product number
- FB147948
- Product name
- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- FB147948
- Product name
- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $122.5
- Updated
- 2021/12/16
- Product number
- FB147948
- Product name
- 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
- Packaging
- 500mg
- Price
- $210
- Updated
- 2021/12/16
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Chemical Properties,Usage,Production
Uses
Pyridine [4,3-D]pyrimidine compounds are nitrogen-containing heterocyclic compounds with unique structures and functions, occupying a very important position in organic chemistry and becoming one of the hot topics in chemical research today. Pyridine [4,3-D]pyrimidine derivatives possess biological activities such as antibacterial, anticancer, anti-inflammatory, antidiabetic, and antiviral activity, and their synthesis has attracted much attention.
Synthesis
A mixture of 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (5.0 g, 0.02 mol), phosphoryl chloride(3.30 mL, 0.035 mol), acetonitrile (80 mL) and DMF (catalytic amount) was heated to at 70° C for 1 hour. The mixture was reduced in vacuo and the remaining black residue was taken up in dichloromethane (250 ml) and poured over ice. The mixture was carefully neutralized with the addition of solid sodium bicarbonate. The layers were separated and the organic dried over sodium sulfate and reduced in vacuo. The mixture was chromatographed using an ethyl acetate: hexanes gradient on an isco flash chromatography system. The combined pure fractions were reduced in vacuo to yield 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine as a yellow oil.
References
[1] Patent: US2006/258689, 2006, A1. Location in patent: Page/Page column 23; 28
[2] Patent: US2008/275037, 2008, A1. Location in patent: Page/Page column 23
[3] Patent: WO2008/123963, 2008, A1. Location in patent: Page/Page column 44
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 11, p. 3124 - 3132
[5] Patent: WO2011/103715, 2011, A1. Location in patent: Page/Page column 40
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine manufacturers
- Product
- 6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE 914612-23-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE 914612-23-0
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 813
- Release date
- 2019-09-02