ANTI-8-HYDROXYGUANOSINE
- Product Name
- ANTI-8-HYDROXYGUANOSINE
- Chemical Name
- ANTI-8-HYDROXYGUANOSINE
- Synonyms
- Anti-8OHG;ANTI-8OHDG;ANTI-8-OHG GOAT PAB;Anti-DNA/RNA Damage;ANTI-8-OXO-G GOAT PAB;ANTI-8-HYDROXYGUANOSINE;ANTI-8-HYDROXYGUANOSINE GOAT PAB;Monoclonal Anti-DNA/RNA Damage antibody produced in mouse
- CBNumber
- CB6298179
- Molecular Formula
- C10H13N5O6
- Formula Weight
- 299.24012
- MOL File
- Mol file
ANTI-8-HYDROXYGUANOSINE Property
- storage temp.
- -20°C
- form
- buffered aqueous glycerol solution
Safety
- WGK Germany
- 1
N-Bromosuccinimide Price
- Product number
- DR1001
- Product name
- Anti-8-Hydroxyguanosine Goat pAb
- Purity
- liquid, Calbiochem?
- Packaging
- 100μL
- Price
- $458
- Updated
- 2024/03/01
- Product number
- SAB5200010
- Product name
- Monoclonal Anti-DNA/RNA Damage antibody produced in mouse
- Purity
- clone 15A3, 1?mg/mL, purified immunoglobulin
- Packaging
- 100μG
- Price
- $503
- Updated
- 2023/06/20
ANTI-8-HYDROXYGUANOSINE Chemical Properties,Usage,Production
General Description
DNA/RNA damage, also known as 8-hydroxyguanine (8-OHG), is a product of oxidized DNA or RNA.
Biochem/physiol Actions
8-hydroxyguanine (8-OHG) helps in determining the reactive oxygen species (ROS)-induced modification of a purine residue in DNA. It is a sensitive marker of oxidative DNA damage. Overexpression of the gene has been observed in diabetic patients, especially those with advanced microvascular complications. Thus, 8-OHG functions as a novel biomarker for identifying oxidative DNA damage in diabetic patients. Plasma level of 8-OHG elevates with the age, with cigarette smoking and during tumorigenesis. 8-OHG levels in urine is considered as a biomarker of the total systemic oxidative stress in vivo. Overexpression of 8-OHG has been observed in various neurodegenerative diseases such as Parkinson′s disease (PD) and multiple system atrophy (MSA).