8-ISO PROSTAGLANDIN E2 ISOPROPYL ESTER Property

Boiling point:

511.8±50.0 °C(Predicted)

Density 

1.079±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: >30 mg/ml (from PGF2a isopropy; DMSO: >50 mg/ml (from PGF2a isopropy; Ethanol: >50 mg/ml (from PGF2a isopropy; PBS pH 7.2: <50 μg/ml (from PGF2a isopropy

pka

13.79±0.60(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

8-ISO PROSTAGLANDIN E2 ISOPROPYL ESTER Chemical Properties,Usage,Production

Description

8-iso PGE₂ isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE₂. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of prostaglandins show greatly diminished agonist activity in vitro compared to the parent free acids.