L-Penicillamine
- Product Name
- L-Penicillamine
- CAS No.
- 1113-41-3
- Chemical Name
- L-Penicillamine
- Synonyms
- l-valin;H-PEN-OH;3-MERCAPTO-L-VALINE;3,3-DIMETHYL-L-CYSTEINE;L-Pen-OH;L-(+)-B2;NSC 241261;3-Mercapto-;3-THIOL-VALINE;-Penicillamine
- CBNumber
- CB6302922
- Molecular Formula
- C5H11NO2S
- Formula Weight
- 149.21
- MOL File
- 1113-41-3.mol
L-Penicillamine Property
- Melting point:
- 206 °C (dec.)(lit.)
- alpha
- 61.9 º (C=0.5 IN 1 M NAOH)
- Boiling point:
- 251.8±35.0 °C(Predicted)
- Density
- 1.113 (estimate)
- refractive index
- 63 ° (C=1, 1mol/L NaOH)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Aqueous Base (Sparingly), DMSO (Slightly, Heated), Water (Slightly)
- pka
- 2.13±0.12(Predicted)
- form
- Crystalline Powder
- color
- White to almost white
- optical activity
- [α]24/D +61.9°, c = 0.5 in 1 M NaOH
- Merck
- 14,7088
- BRN
- 1722374
- Stability:
- Hygroscopic
- InChIKey
- VVNCNSJFMMFHPL-GSVOUGTGSA-N
- CAS DataBase Reference
- 1113-41-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-40-20/21/22
- Safety Statements
- 26-36-22-24/25
- WGK Germany
- 2
- RTECS
- YV9445500
- HS Code
- 29309090
- Toxicity
- LD50 i.p. in rats: 350 mg/kg (Jaffe)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 196312
- Product name
- L-Penicillamine
- Purity
- 99%
- Packaging
- 1g
- Price
- $77.7
- Updated
- 2024/03/01
- Product number
- 196312
- Product name
- L-Penicillamine
- Purity
- 99%
- Packaging
- 5g
- Price
- $264
- Updated
- 2024/03/01
- Product number
- P1370
- Product name
- L-Penicillamine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- P1370
- Product name
- L-Penicillamine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- L13923
- Product name
- L-(+)-Penicillamine, 98+%
- Packaging
- 250mg
- Price
- $0
- Updated
- 2021/12/16
L-Penicillamine Chemical Properties,Usage,Production
Chemical Properties
white to almost white crystalline powder
Uses
L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
Uses
Metal-chelating agent
Uses
As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
Indications
Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness.The response to penicillamine is usually delayed (4–12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug’s efficacy is limited; thus, penicillamine is seldom used to treat rheumatoid arthritis.
Definition
ChEBI: The L-enantiomer of penicillamine.
Mechanism of action
The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication.
Pharmacology
Penicillamine is readily absorbed from the GI tract and is rapidly excreted in the urine, largely as the intact molecule. Gradually increasing its dose minimizes side effects, which necessitate discontinuance of penicillamine therapy in perhaps one-third of patients. The most common side effects are maculopapular pruritic dermatitis, GI upset, loss of taste sensation, mild to occasionally severe thrombocytopenia and leukopenia,and mild proteinuria, which at times may progress to the nephritic syndrome. Discontinuance of therapy usually results in a rapid disappearance of side effects.
Safety Profile
A poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx and SOx.
Purification Methods
Same as preceding entry for its enantiomer. [Beilstein 4 IV 3228.]
L-Penicillamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Penicillamine manufacturers
- Product
- L-Penicillamine 1113-41-3
- Price
- US $8.00-3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03
- Product
- L-penicillamine 1113-41-3
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2022-09-29
- Product
- L-Penicillamine 1113-41-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10