ChemicalBook > CAS DataBase List > Lumateperone

Lumateperone

Physical Form

Product Name: Lumateperone
CAS No.: 313368-91-1
Chemical Name: Lumateperone
Synonyms: Lumateperone;ITI-722;Lumepperone;Lumiperidone;ITI-722 lumateperone;Lumateperone ITI-722;Lumateperone, 10 mM in DMSO;313368-91-1Lumateperone(ITI-007);1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3‘,4‘:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)butan-1-one;1-(4-Fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone
CBNumber: CB63032893
Molecular Formula: C24H28FN3O
Formula Weight: 393.5
MOL File: 313368-91-1.mol

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Lumateperone Property

Boiling point:: 556.4±50.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
pka: 9.10±0.20(Predicted)
form: Oil
color: Colorless to light yellow
InChIKey: HOIIHACBCFLJET-SFTDATJTSA-N
SMILES: C(C1=CC=C(F)C=C1)(=O)CCCN1C[C@@]2([H])C3=CC=CC4=C3N([C@@]2([H])CC1)CCN4C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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Lumateperone Chemical Properties,Usage,Production

Physical Form

white solid

Description

Lumateperone is a novel antipsychotic agent with a unique mechanism of action with high 5-hydroxytryptamine 2A(5-HT2A) blocking activity. A Phase 2 study in treatment of insomnia revealed strong evidence of efficacy, with no impairment of next-day cognition.

Uses

Lumateperone was a drug developed for the treatment of schizophrenia. May have applications in bipolar depression.

Synthesis

Synthesis of Lumateperone

in vivo

Lumateperone (i.p., 1-10 mg/kg) promotes NMDA and AMPA-induced currents in a dopamine D1 receptor-dependent manner and increases the release of dopamine and glutamate in rat mPFC slices^[2].

Animal Model:	Adult male Sprague-Dawley rats^[2]
Dosage:	1-10 mg/kg
Administration:	Intraperitoneal injection
Result:	Inhibited avoidance response at concentrations of 1, 3 and 10 mg/kg after 20 minutes. Promoted NMDA and AMPA-sensitive currents, also significantly increased dopamine and glutamate release at 10 mg/kg in mPFC cone cells of rat.

IC 50

D₁ Receptor; D₂ Receptor

storage

Store at 0-8℃

References

[1] Patent: US2004/220178, 2004, A1

Lumateperone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lumateperone manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Lumateperone 313368-91-1
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2025-03-26

shandong perfect biotechnology co.ltd

Product: Lumateperone 313368-91-1
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100g
Release date: 2023-08-01

Chengdu Aupone Pharmaceutical Co.Ltd.

Product: Lumateperone 313368-91-1
Price: US $0.00/gram
Min. Order: 10gram
Purity: 99.99
Supply Ability: 10Tons
Release date: 2024-03-18

313368-91-1, LumateperoneRelated Search:

ITI-722

Lumateperone

ITI-722 lumateperone

1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3‘,4‘:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)butan-1-one

313368-91-1Lumateperone(ITI-007)

1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-

1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one

1-(4-Fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone

presynaptic D2 receptor,dopamine D1 receptor,Serotonin Receptor,postsynaptic D2 receptor,Dopamine Receptor,5-HT2A,schizophrenia,ITI 007,Lumateperone,inhibit,Inhibitor,5-HT Receptor,5-hydroxytryptamine Receptor

Lumateperone ITI-722

Lumepperone

Lumateperone, 10 mM in DMSO

Lumiperidone

1-(4-fluorophenyl)-4-((6br,10as)-3-methyl-2,3,6b,9,10,10a-hexahydro-1h-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7h)-yl)butan-1-one

313368-91-1

C24H28FN3O

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