Sappanone A

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Product Name: Sappanone A
CAS No.: 102067-84-5
Chemical Name: Sappanone A
Synonyms: Sappanone A;3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one;(E)-7-hydroxy-3-[(3,4-dihydroxyphenyl)methylene]-chroman-4-one;3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-
CBNumber: CB63037515
Molecular Formula: C16H12O5
Formula Weight: 284.26
MOL File: 102067-84-5.mol

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Sappanone A Property

Boiling point:: 605.5±55.0 °C(Predicted)
Density: 1.521±0.06 g/cm3(Predicted)
solubility: DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.25 mg/ml
form: A solid
pka: 7.20±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23205
Product name: Sappanone A
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23205
Product name: Sappanone A
Purity: ≥98%
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Cayman Chemical

Product number: 23205
Product name: Sappanone A
Purity: ≥98%
Packaging: 10mg
Price: $252
Updated: 2024/03/01

Cayman Chemical

Product number: 23205
Product name: Sappanone A
Purity: ≥98%
Packaging: 25mg
Price: $550
Updated: 2024/03/01

Cayman Chemical

Product number: 23205
Product name: SappanoneA
Purity: ≥98%
Packaging: 50mg
Price: $792
Updated: 2021/12/16

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Sappanone A Chemical Properties,Usage,Production

Description

Sappanone A is a homoisoflavonoid with diverse biological activities that has been isolated from the aerial parts of C. pulcherrima, the heartwood of C. sappan, and the stems of H. campechianum. In vitro, sappanone A inhibits 76.2, 59.2, 37.4, and 35.4% of FGFR1, KDR, c-Met, and c-Kit kinase activity, respectively, when used at a concentration of 10 μM. It also inhibits influenza viral neuraminidase (NA) with IC₅₀ values of 0.7, 1.1, and 1 μM for H1N1, H3N2, and H9N2 influenza viral NAs, respectively. Sappanone A has antibacterial activity against Gram-positive B. subtilis, B. sphaericus, and S. aureus as well as Gram-negative K. aerogenes and C. violaceum. It also inhibits the growth of A. niger and C. albicans fungi. Sapannone A inhibits LPS-induced inflammatory responses in vitro and in vivo, reducing nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E₂ (PGE₂; ) production in RAW264.7 cells as well as LPS-induced mortality in mice. It also attenuates airway inflammation and mucus hypersecretion via activation of the Nrf2 signaling pathway in a mouse model of ovalbumin-induced asthma.

Uses

Sappanone A is a natural product flavonoid with some antioxidant properties that can be isolated from C. sappan.

Biological Activity

Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.

Sappanone A Preparation Products And Raw materials

Raw materials

Preparation Products

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102067-84-5, Sappanone ARelated Search:

Triptolide

Sappanone A

3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one

(E)-7-hydroxy-3-[(3,4-dihydroxyphenyl)methylene]-chroman-4-one

3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one

4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-

102067-84-5