sbc-115076

Product Name: sbc-115076
CAS No.: 489415-96-5
Chemical Name: sbc-115076
Synonyms: CS-1638;CS-2068;sbc-115076;SBC-115076, 10 mM in DMSO;SBC-115076;SBC 115076;SBC115076;4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1,5-dihydro-2H-pyrrol-2-one;4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione;1,5-Dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one;2H-Pyrrol-2-one, 1,5-dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-;Inhibitor,inhibit,sensitivity,Ser/Thr Protease,LDL,HFD-fed,obesity,Serine proteases,rats,SBC 115076,SBC-115076,Threonine proteases,Serine endopeptidases,insulin
CBNumber: CB63038769
Molecular Formula: C31H33N3O5
Formula Weight: 527.61
MOL File: 489415-96-5.mol

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sbc-115076 Property

Boiling point:: 754.2±60.0 °C(Predicted)
Density: 1.266±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:46.0(Max Conc. mg/mL);87.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.95(Max Conc. mM)
DMF:2.0(Max Conc. mg/mL);3.79(Max Conc. mM)
form: A crystalline solid
pka: 4.50±1.00(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1712
Product name: SBC-115076
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $126
Updated: 2025/07/31

Cayman Chemical

Product number: 19134
Product name: SBC-115076
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19134
Product name: SBC-115076
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19134
Product name: SBC-115076
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 19134
Product name: SBC-115076
Purity: ≥98%
Packaging: 25mg
Price: $396
Updated: 2024/03/01

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sbc-115076 Chemical Properties,Usage,Production

Uses

SBC-115,076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compound used in treatment and/or prevention of cardiovascular diseases and hypercholesterolemia.

Biological Activity

SBC-115076 is an inhibitor of PCSK9 (proprotein convertase subtilisin-kexin 9). PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. SBC-115076 was shown to inihbit PCSK9, blocking LDLR degradation in HEK293T cells expressing PCSK9 and to increase the uptake of LDL by liver cells in vitro. SBC-115076 lowered cholesterol levels in mice fed a high f at diet.

in vivo

SBC-115076 (4 mg/kg; s.c.; daily for 3 weeks) reduces obesity and dyslipidemia, as well as improves insulin sensitivity in HFD-fed rats^[1].

Animal Model:	Female Wistar rats (high-fat diet (HFD)- fed)^[1]
Dosage:	4 mg/kg
Administration:	S.c.; daily for 3 weeks
Result:	Superior to atorvastatin in instigating weight loss, cholesterol reduction, and attenuation of mitochondrial oxidative stress in oxidative muscle fibers of obese female rats.

sbc-115076 Preparation Products And Raw materials

Raw materials

Preparation Products

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sbc-115076 Suppliers

China 67 United Kingdom 1 United States 11 Global 79

Target molecule Corp.

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Musechem

Tel: +1-800-259-7612
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TargetMol Chemicals Inc.

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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
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United States Biological

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489415-96-5, sbc-115076Related Search:

sbc-115076

4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione

1,5-Dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one

SBC-115076;SBC 115076;SBC115076

CS-2068

CS-1638

2H-Pyrrol-2-one, 1,5-dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-

4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1,5-dihydro-2H-pyrrol-2-one

Inhibitor,inhibit,sensitivity,Ser/Thr Protease,LDL,HFD-fed,obesity,Serine proteases,rats,SBC 115076,SBC-115076,Threonine proteases,Serine endopeptidases,insulin

SBC-115076, 10 mM in DMSO

489415-96-5

Inhibitors