ChemicalBook > CAS DataBase List > (R)-1-benzyl-5-methyl-1,4-diazepane
(R)-1-benzyl-5-methyl-1,4-diazepane
Appearance- Product Name
- (R)-1-benzyl-5-methyl-1,4-diazepane
- CAS No.
- 1620097-06-4
- Chemical Name
- (R)-1-benzyl-5-methyl-1,4-diazepane
- Synonyms
- (R)-1-benzyl-5-methyl-1,4-diazepane;(5R)-1-benzyl-5-methyl-1,4-diazepane;Relebactam Impurity 4;Suvorexant Impurity 27;Suvorexant (MK-4305) intermediate;(R)-1-benzyl-5-methyl-1,4-diazepane(For export only);(5S)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine;(5R)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine;1H-1,4-Diazepine, hexahydro-5-methyl-1-(phenylmethyl)-, (5R)-;Suvorexant intermediate (5R)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine
- CBNumber
- CB63040519
- Molecular Formula
- C13H20N2
- Formula Weight
- 204.31
- MOL File
- 1620097-06-4.mol
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(R)-1-benzyl-5-methyl-1,4-diazepane Property
- Boiling point:
- 296.1±28.0 °C(Predicted)
- Density
- 0.974±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 10.65±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 0340DJ
- Product name
- (R)-1-Benzyl-5-methyl-1,4-diazepane
- Packaging
- 10g
- Price
- $456
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- APN0008416
- Product name
- 1H-1,4-DIAZEPINE, HEXAHYDRO-5-METHYL-1-(PHENYLMETHYL)-, (5R)-
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.27
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0340DJ
- Product name
- (R)-1-Benzyl-5-methyl-1,4-diazepane
- Packaging
- 5g
- Price
- $304
- Updated
- 2021/12/16
Chemenu
- Product number
- CM104875
- Product name
- (5R)-1-benzyl-5-methyl-1,4-diazepane
- Purity
- 95+%
- Packaging
- 10g
- Price
- $330
- Updated
- 2021/12/16
Alichem
- Product number
- 1620097064
- Product name
- (R)-1-Benzyl-5-methyl-1,4-diazepane
- Packaging
- 5g
- Price
- $499.2
- Updated
- 2021/12/16
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(R)-1-benzyl-5-methyl-1,4-diazepane Chemical Properties,Usage,Production
Appearance
White crystal
Uses
(5R)-1-Benzyl-5-methyl-1,4-diazepane is a synthetic substance with inhibitory activity on calcium channels. It has been shown to be useful for the treatment of epilepsy and other neurological disorders in animal models.
Synthesis
The synthesis of (5R)-1-benzyl-5-methyl-1,4-diazepane was achieved by a two step process that involved the coupling of benzaldehyde and methyl vinyl ketone followed by the formation of an azide from methyl nitrite. This substance was purified using liquid chromatography and high performance liquid chromatography, which yielded a purity of 99%. A validation study confirmed that the impurities did not exceed 1% in concentration.
Preparation
(R)-4-benzyl-7-methyl-1,4-diazepan-2,5-dione(6 mmol)Was dissolved in 60 ml of dry THF, and 1.35 g of LiAlH4 (36 mmol) was added portionwise under ice-cooling, and stirred at 25℃ for 4 h.After cooling to -10 ℃, 1.5 ml of H20 was added and 1.5 ml of 15% NaOH, 4.5 ml of H20 and a portion of MgS04 were added, stirred for 1 h, suction filtered and dried to afford 1.2 g of an oil yield 97.56%。
(R)-1-benzyl-5-methyl-1,4-diazepane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-1-benzyl-5-methyl-1,4-diazepane manufacturers
Jiangsu Guotai Guomian Trading Co. Ltd.
- Product
- (R)-1-benzyl-5-methyl-1,4-diazepane 1620097-06-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- In house standard
- Supply Ability
- 1 ton
- Release date
- 2023-02-06
Career Henan Chemical Co
- Product
- Suvorexantintermediate 1620097-06-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09
1620097-06-4, (R)-1-benzyl-5-methyl-1,4-diazepaneRelated Search:
Suvorexant intermediate
(R)-(7-Methyl-1,4-diazepan-1-yl)(5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)Methanone
Suvorexant intermediate
Suvorexant
intermediate
1H-1,4-Diazepine-1-carboxylic acid, hexahydro-5-Methyl-, phenylMethyl ester, (5R)-
5-Methyl-2-(1H-1,2,3-triazol-1-yl)benzoic acid
(R)-5-chloro-2-(5-Methyl-1,4-diazepan-1-yl)benzo[d]oxazole hydrochloride