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ML352

Product Name
ML352
CAS No.
1649450-12-3
Chemical Name
ML352
Synonyms
ML352;CS-1661;VU-0476201;VU-0476201;CS-1661;ML-352;4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-N-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide;N-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide , ML352;Benzamide, 4-methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]-
CBNumber
CB63040791
Molecular Formula
C21H29N3O4
Formula Weight
387.47
MOL File
1649450-12-3.mol
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ML352 Property

Boiling point:
538.1±50.0 °C(Predicted)
Density 
1.145±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
Powder
pka
13.03±0.46(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21878
Product name
ML-352
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
21878
Product name
ML-352
Purity
≥98%
Packaging
5mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
21878
Product name
ML-352
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
TRC
Product number
M425350
Product name
ML352
Packaging
50mg
Price
$340
Updated
2021/12/16
ApexBio Technology
Product number
B5897
Product name
ML352
Packaging
10mg
Price
$201
Updated
2021/12/16
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ML352 Chemical Properties,Usage,Production

Uses

ML352 is a novel, noncompetitive inhibitor of the presynaptic choline transporter (1).

Biological Activity

the neurotransmitter acetylcholine (ach) plays a critical role in autonomic function, motor control, attention, learning, and memory, and reward. the high-affinity choline transporter (cht) is the ratelimiting determinant of ach synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. ml352 is a novel, noncompetitive inhibitor of the presynaptic choline transporter.

in vitro

at concentrations fully antagonized cht in transfected cells and nerve terminal preparations, ml352 exhibited no inhibition of acetylcholinesterase or cholineacetyltransferase and also lacked activity at dopamine, serotonin, and norepinephrine transporters, as well as many receptors and ion channels. ml352 exhibited noncompetitive choline uptake inhibition in intact cells and reduced the apparent density of hemicholinium-3 binding sites in membrane assays, indicating allosteric transporter interactions [1].

in vivo

dmpk studies revealed a high intravenous plasma clearance, a combination of the oral bioavailability and total brain concentrations indicate ml352 to be a suitable probe for studies of altered in vivo ach signaling and behavioral effects in rodents [2].

References

[1] ennis ea, wright j, retzlaff cl, mcmanus ob, lin z, huang x, wu m, li m, daniels js, lindsley cw, hopkins cr, blakely rd. identification and characterization of ml352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. acs chem neurosci. 2015 mar 18;6(3):417-27.
[2] elizabeth ennis miss, jane wright, james tarr, charles locuson, corey hopkins, j daniels, craig lindsley and randy blakely. a novel approach to cholinergic signaling modulation: development and characterization of ml352, a novel, noncompetitive inhibitor of the presynaptic choline transporter. the faseb journal vol. 29 no. 1 supplement 932.6

ML352 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML352 Suppliers

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1649450-12-3, ML352Related Search:


  • ML352
  • CS-1661
  • VU-0476201
  • VU-0476201;CS-1661;ML-352
  • Benzamide, 4-methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]-
  • 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-N-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide
  • N-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide , ML352
  • 1649450-12-3