2-fluoro-4-nitrobenzene-1-sulfonyl chloride
- Product Name
- 2-fluoro-4-nitrobenzene-1-sulfonyl chloride
- CAS No.
- 1146290-36-9
- Chemical Name
- 2-fluoro-4-nitrobenzene-1-sulfonyl chloride
- Synonyms
- 2-Fluoro-4-nitrobenzenesulfonyl chloride;2-fluoro-4-nitrophenylsulfonyl chloride;2-Fluoro-4-nitrobenzenesulphonyl chloride;Benzenesulfonyl chloride, 2-fluoro-4-nitro-;2-fluoro-4-nitrobenzene-1-sulfonyl chloride
- CBNumber
- CB63041011
- Molecular Formula
- C6H3ClFNO4S
- Formula Weight
- 239.61
- MOL File
- 1146290-36-9.mol
2-fluoro-4-nitrobenzene-1-sulfonyl chloride Property
- Boiling point:
- 338.2±27.0 °C(Predicted)
- Density
- 1.685±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline powder
- color
- Off-white to faint yellow
Safety
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- F597595
- Product name
- 2-Fluoro-4-nitrobenzene-1-sulfonylchloride
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- PC501516
- Product name
- 2-Fluoro-4-nitrobenzenesulphonylchloride
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 8662-D-04
- Product name
- 2-Fluoro-4-nitrobenzenesulfonyl chloride
- Packaging
- 250mg
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 9988AF
- Product name
- 2-Fluoro-4-nitrobenzene-1-sulfonylchloride
- Packaging
- 250mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- PC501516
- Product name
- 2-Fluoro-4-nitrobenzenesulphonylchloride
- Packaging
- 1g
- Price
- $212
- Updated
- 2021/12/16
2-fluoro-4-nitrobenzene-1-sulfonyl chloride Chemical Properties,Usage,Production
Synthesis
1242618-52-5
1146290-36-9
General procedure for the synthesis of 2-fluoro-4-nitrobenzenesulfonyl chloride from 1-(benzylsulfonyl)-2-fluoro-4-nitrobenzene: To a cooled 1-(benzylsulfonyl)-2-fluoro-4-nitrobenzene (10.5 g, 40.0 mmol) solution of acetonitrile-acetic acid-water (400 mL, 5 mL, 10 mL) was added in batches 1,3-dichloro-5,5-dimethyl-acetonitrile ( 15.8 g, 80.0 mmol). The reaction was carried out at 0°C. After stirring at 0°C for 3 h, the reaction mixture was concentrated in vacuum to near dryness. The crude product was diluted with dichloromethane (500 mL) and the solution was cooled to about 0°C. A 5% aqueous sodium bicarbonate solution (550 mL) was added slowly at a temperature below 10°C and the mixture was stirred at 0°C for 15 minutes. The organic layer was separated, washed with cooled brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The resulting liquid product was used for subsequent reactions without further purification. A small amount of analytically pure sample was obtained by purification on preparative thin layer chromatography plate (9:1 hexane/ethyl acetate) to afford 2-fluoro-4-nitrobenzenesulfonyl chloride (71% yield) as a light yellow solid with melting point 44-45 °C (literature value 45-47 °C).1H NMR (CDCl3) δ 8.32 (dd, J = 9.0,5.0 Hz, 1H, Ar-H), 7.64 (dd, J = 7.5,2.5 Hz, 1H, Ar-H), 7.61-7.57 (m, 1H, Ar-H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1569 - 1574
[2] Tetrahedron, 2010, vol. 66, # 32, p. 5982 - 5986
[3] Patent: WO2017/156181, 2017, A1. Location in patent: Paragraph 00363
2-fluoro-4-nitrobenzene-1-sulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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