3-methyl toxoflavin
- Product Name
- 3-methyl toxoflavin
- CAS No.
- 32502-62-8
- Chemical Name
- 3-methyl toxoflavin
- Synonyms
- 3-methyl toxoflavin;trimethyl-1H,5H,6H,7H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione;1,3,6-Trimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione;Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,3,6-trimethyl-;Inhibitor,3 Methyltoxoflavin,3-Methyltoxoflavin,3Methyltoxoflavin,inhibit
- CBNumber
- CB63041187
- Molecular Formula
- C8H9N5O2
- Formula Weight
- 207.19
- MOL File
- 32502-62-8.mol
3-methyl toxoflavin Property
- Boiling point:
- 285.0±23.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 150 mg/mL (723.97 mM)
- form
- Solid
- pka
- -1.80±0.20(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CHM0292770
- Product name
- 1,3,6-TRIMETHYL-PYRIMIDO[5,4-E]-1,2,4-TRIAZINE-5,7(1H,6H)-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.86
- Updated
- 2021/12/16
- Product number
- orb573135
- Product name
- 3-methyl toxoflavin
- Purity
- >98%
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
- Product number
- orb573135
- Product name
- 3-methyl toxoflavin
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1283.5
- Updated
- 2021/12/16
- Product number
- orb573135
- Product name
- 3-methyl toxoflavin
- Purity
- >98%
- Packaging
- 1g
- Price
- $2395.3
- Updated
- 2021/12/16
- Product number
- CSN24071
- Product name
- 35G8
- Packaging
- 10mg
- Price
- $221
- Updated
- 2021/12/16
3-methyl toxoflavin Chemical Properties,Usage,Production
Definition
ChEBI: 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione is a pyrimidotriazine.
Biological Activity
3-Methyltoxoflavin is a potent inhibitor of protein disulfide isomerase (PDI) with IC50 of 170 nM.
in vitro
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC 50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy . Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis.
target
IC50: 170 nM (PDI).
3-methyl toxoflavin Preparation Products And Raw materials
Raw materials
Preparation Products
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