ChemicalBook > CAS DataBase List > K-Ras-IN-1
K-Ras-IN-1
- Product Name
- K-Ras-IN-1
- CAS No.
- 84783-01-7
- Chemical Name
- K-Ras-IN-1
- Synonyms
- Mdk-3017;K-Ras-IN-1;K-Ras inhibitor 1;K-Ras-IN-1, 10 mM in DMSO;2-(Pyrrolidine-1-carbothioyl)phenol;Methanethione, (2-hydroxyphenyl)-1-pyrrolidinyl-;(2-Hydroxy-phenyl)-pyrrolidin-1-yl-methanethione;Inhibitor,mutations,Ras,K-Ras,pancreatic,carcinomas,lung,colon,KRasIN1,K Ras IN 1,inhibit
- CBNumber
- CB63041420
- Molecular Formula
- C11H13NOS
- Formula Weight
- 207.29
- MOL File
- 84783-01-7.mol
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K-Ras-IN-1 Property
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO : ≥ 28 mg/mL (135.08 mM)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-4934
- Product name
- K-Ras-IN-1
- Purity
- 98.13%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-4934
- Product name
- K-Ras-IN-1
- Purity
- 98.13%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-4934
- Product name
- K-Ras-IN-1
- Purity
- 98.13%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
Ambeed
- Product number
- A234456
- Product name
- Mdk-3017
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $479
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN18462
- Product name
- MDK-3017
- Packaging
- 10mg
- Price
- $510
- Updated
- 2021/12/16
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K-Ras-IN-1 Chemical Properties,Usage,Production
Uses
K-Ras-IN-1 is the inhibitor for K-Ras by occupying the binding site of son of sevenless (Sos), preventing the interaction between Sos and K-Ras, inhibiting the Sos-catalyzed GDP to GTP exchange process. K-Ras-IN-1 is promising for research of pancreatic, colon and lung cancer[1][2].
References
[1] Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538. DOI:10.1021/ci400474u
[2] Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3. DOI:10.1002/anie.201201358
K-Ras-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from K-Ras-IN-1 manufacturers
Career Henan Chemical Co
- Product
- K-Ras-IN-1 84783-01-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05