1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one

ChemicalBook > CAS DataBase List > 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one

1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one

Product Name: 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one
CAS No.: 1620576-64-8
Chemical Name: 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one
Synonyms: CS-1592;AZD-8835;AZD 8835; AZD8835.;inhibit,PI3K,Inhibitor,AZD 8835,AZD-8835,Phosphoinositide 3-kinase;1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one;1-Propanone, 1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-3-hydroxy-
CBNumber: CB63044380
Molecular Formula: C22H31N9O3
Formula Weight: 469.54
MOL File: 1620576-64-8.mol

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1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one Property

Boiling point:: 784.0±70.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A crystalline solid
pka: 14.68±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29166
Product name: AZD 8835
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29166
Product name: AZD 8835
Packaging: 25mg
Price: $442
Updated: 2024/03/01

Cayman Chemical

Product number: 29166
Product name: AZD 8835
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 29166
Product name: AZD 8835
Packaging: 10mg
Price: $213
Updated: 2024/03/01

ChemScene

Product number: CS-4984
Product name: AZD-8835
Purity: 98.63%
Packaging: 25mg
Price: $250
Updated: 2021/12/16

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1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one Chemical Properties,Usage,Production

Uses

AZD-8835 can be used as an inhibitor in biological cell and animal experiments.

Biological Activity

azd8835 is a dual pi3kα and pi3kδ inhibitor.the pik3ca gene, encoding the p110α catalytic unit of pi3kα, is one of the most mutated oncogenes in human cancer. therefore, pi3kα is a critical target in identifying inhibitors and testing their therapeutic application.

in vitro

azd8835 was identified as a potent dual inhibitor of pi3kα and pi3kδ with good selectivity versus pi3kβ, pi3kγ, as well as other kinases that readily inhibited cell growth with mutant pik3ca status, such as in estrogen receptor-positive breast cancer cell lines including mcf7, bt474, and t47d [1].

in vivo

previous animal study demonstrated that azd8835 had antitumor efficacy in breast cancer xenograft models when azd8835 was continuously dosed. in addition, the monotherapy of azd8835 was found to be able to induce tumor xenograft regression by using intermittent high-dose scheduling (ihds). furthermore, azd8835 ihds treatment in combination with other targeted therapeutic agents could further enhance its antitumor activity by up to 92% regression [1].

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> PI3Kγ
(Cell-based assay)

Target	Value
PI3Kδ (Cell-based assay)	5.7 nM
PI3Kα (Cell-free assay)	6.2 nM
90 nM
PI3Kβ (Cell-based assay)	431 nM

IC 50

6.2 and 5.7 nm for pi3kα and pi3kδ, respectively

References

[1] hudson k et al. intermittent high-dose scheduling of azd8835, a novel selective inhibitor of pi3kα and pi3kδ, demonstrates treatment strategies for pik3ca-dependent breast cancers. mol cancer ther.2016 may;15(5):877-89.

1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one Suppliers

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1620576-64-8, 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-oneRelated Search:

1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one

AZD-8835

AZD 8835; AZD8835.

CS-1592

1-Propanone, 1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-3-hydroxy-

inhibit,PI3K,Inhibitor,AZD 8835,AZD-8835,Phosphoinositide 3-kinase

1620576-64-8

C22H31N9O3