2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid

Product Name: 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
CAS No.: 1572936-83-4
Chemical Name: 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
Synonyms: MONNA, 10 mM in DMSO;Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel;2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid;2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid;Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
CBNumber: CB63049204
Molecular Formula: C18H14N2O5
Formula Weight: 338.31
MOL File: 1572936-83-4.mol

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2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Property

Boiling point:: 553.1±50.0 °C(Predicted)
Density: 1.421±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble
form: A crystalline solid
pka: 2.26±0.22(Predicted)
color: Brown to dark brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21917
Product name: MONNA
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21917
Product name: MONNA
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 21917
Product name: MONNA
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 21917
Product name: MONNA
Purity: ≥98%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

TRC

Product number: M226500
Product name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoicAcid
Packaging: 5mg
Price: $85
Updated: 2021/12/16

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2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Chemical Properties,Usage,Production

Description

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC₅₀ = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

Uses

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

storage

Store at +4°C

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Suppliers

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1572936-83-4, 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acidRelated Search:

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid

Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-

Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel

MONNA, 10 mM in DMSO

1572936-83-4