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JAK3-IN-1

Product Name
JAK3-IN-1
CAS No.
1805787-93-2
Chemical Name
JAK3-IN-1
Synonyms
JAK3-IN-1;JAK3 inhibitor 1;JAK-3-IN-1,JAK3 IN 1,JAK3IN1;2-Propenamide, N-[3-[[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-
CBNumber
CB63053896
Molecular Formula
C26H30ClN7O2
Formula Weight
508.02
MOL File
1805787-93-2.mol
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JAK3-IN-1 Property

Density 
1.315±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 47 mg/mL (92.52 mM)
form 
Solid
pka
13.48±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5283
Product name
JAK3-IN-1
Purity
99.98%
Packaging
5mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-5283
Product name
JAK3-IN-1
Purity
99.98%
Packaging
10mg
Price
$600
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611792
Product name
JAK3-IN-1
Packaging
10mg
Price
$615.4
Updated
2021/12/16
ChemScene
Product number
CS-5283
Product name
JAK3-IN-1
Purity
99.98%
Packaging
50mg
Price
$1800
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611792
Product name
JAK3-IN-1
Packaging
50mg
Price
$1802
Updated
2021/12/16
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JAK3-IN-1 Chemical Properties,Usage,Production

Uses

JAK3-IN-1 is a potent, selective and orally active JAK3 inhibitor with an IC50 of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC50 of 896 nM) and JAK2 (IC50 of 1050 nM)[1].

in vivo

JAK3-IN-1(Compound 9) shows reasonable pharmacokinetic properties, with moderate T1/2 of 1.4 h, area under the curve (AUC) value of 795 ng*hr/mL following a 10 mg/Kg oral dose and good oral bioavailability of 66%. After oral administration with JAK3-IN-1(Compound 9) (75 mpk, QD) for 8 days, the numbers of B or T lymphocytes in the tumor-bearing lungs and spleens of treated mice is not affected, however, the number of NK cells is reduced[1].

IC 50

JAK3: 4.8 nM (IC50); JAK1: 896 nM (IC50); JAK2: 1050 nM (IC50); TTK: 49 nM (IC50); BTK: 794 nM (IC50); ITK: 1070 nM (IC50)

References

[1] Tan L, et al. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27;58(16):6589-6606. DOI:10.1021/acs.jmedchem.5b00710

JAK3-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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JAK3-IN-1 Suppliers

China 27 United States 5 Global 32
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
9697
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Rlavie Technology Co., Ltd.
Tel
21-67759270 17717059219
Fax
QQ：1479352695
Email
sales@rlavie.com
Country
China
ProdList
1730
Advantage
55
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58

1805787-93-2, JAK3-IN-1Related Search:


  • JAK3-IN-1
  • JAK3 inhibitor 1
  • 2-Propenamide, N-[3-[[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-
  • JAK-3-IN-1,JAK3 IN 1,JAK3IN1
  • 1805787-93-2