(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
- Product Name
- (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
- CAS No.
- 1082066-29-2
- Chemical Name
- (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
- Synonyms
- 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan.;3-Fluoro-4-(hydroxymethyl)phenylboronic acid Pinacol Ester;2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol;(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol;Benzenemethanol, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber
- CB63062872
- Molecular Formula
- C13H18BFO3
- Formula Weight
- 252.09
- MOL File
- 1082066-29-2.mol
(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4721AJ
- Product name
- (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
- Packaging
- 1g
- Price
- $367
- Updated
- 2021/12/16
- Product number
- PC510176
- Product name
- 3-Fluoro-4-(hydroxymethyl)phenylboronic acid Pinacol Ester
- Packaging
- 1g
- Price
- $978
- Updated
- 2021/12/16
- Product number
- 6660-3-1G
- Product name
- 3-Fluoro-4-(hydroxymethyl)phenylboronic acid, pinacol ester
- Packaging
- 1g
- Price
- $1159
- Updated
- 2021/12/16
- Product number
- 1082066292
- Product name
- (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- UT00392
- Product name
- (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
- Purity
- 97%
- Packaging
- 5g
- Price
- $693.98
- Updated
- 2021/12/16
(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Chemical Properties,Usage,Production
Synthesis
73183-34-3
188582-62-9
1082066-29-2
3.1.1. Preparation of (2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (934-2) To a stirred solution of 4-bromo-2-fluorobenzyl alcohol (500 mg, 2.44 mmol) in dioxane (5 mL) under nitrogen protection was sequentially added pinacol ester of biboronate (929 mg, 3.66 mmol), [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride dichloromethane complex (198 mg, 0.24 mmol) and potassium acetate (717 mg, 7.32 mmol). The reaction mixture was stirred at 90 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate and water by partitioning. The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 0-20% gradient) to afford the title compound (2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (934-2) (300 mg, 48% yield) as a yellow oil.
References
[1] Patent: US2018/194762, 2018, A1. Location in patent: Paragraph 0740-0741
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 18, p. 4984 - 4995
(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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